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Conflicting Roles of 20-HETE in Hypertension and Stroke

1
Department of Neurology, University of Mississippi Medical Center, Jackson, MS 39216, USA
2
Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, MS 39216, USA
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2019, 20(18), 4500; https://doi.org/10.3390/ijms20184500
Received: 17 July 2019 / Revised: 28 August 2019 / Accepted: 8 September 2019 / Published: 11 September 2019
(This article belongs to the Special Issue Molecular Advances in Hypertension)
Hypertension is the most common modifiable risk factor for stroke, and understanding the underlying mechanisms of hypertension and hypertension-related stroke is crucial. 20-hydroxy-5, 8, 11, 14-eicosatetraenoic acid (20-HETE), which plays an important role in vasoconstriction, autoregulation, endothelial dysfunction, angiogenesis, inflammation, and blood-brain barrier integrity, has been linked to hypertension and stroke. 20-HETE can promote hypertension by potentiating the vascular response to vasoconstrictors; it also can reduce blood pressure by inhibition of sodium transport in the kidney. The production of 20-HETE is elevated after the onset of both ischemic and hemorrhagic strokes; on the other hand, subjects with genetic variants in CYP4F2 and CYP4A11 that reduce 20-HETE production are more susceptible to stroke. This review summarizes recent genetic variants in CYP4F2, and CYP4A11 influencing 20-HETE production and discusses the role of 20-HETE in hypertension and the susceptibility to the onset, progression, and prognosis of ischemic and hemorrhagic strokes. View Full-Text
Keywords: cytochrome P450; hypertension; stroke; cerebral autoregulation; endothelial dysfunction; vascular remodeling; vascular inflammation; blood-brain barrier; angiogenesis cytochrome P450; hypertension; stroke; cerebral autoregulation; endothelial dysfunction; vascular remodeling; vascular inflammation; blood-brain barrier; angiogenesis
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MDPI and ACS Style

Shekhar, S.; Varghese, K.; Li, M.; Fan, L.; Booz, G.W.; Roman, R.J.; Fan, F. Conflicting Roles of 20-HETE in Hypertension and Stroke. Int. J. Mol. Sci. 2019, 20, 4500.

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