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Article

Role of B-Cell Translocation Gene 1 in the Pathogenesis of Endometriosis

by
Jeong Sook Kim
1,
Young Sik Choi
2,3,
Ji Hyun Park
4,
Jisun Yun
2,
Soohyun Kim
4,
Jae Hoon Lee
2,
Bo Hyon Yun
2,3,
Joo Hyun Park
3,4,
Seok Kyo Seo
2,3,
SiHyun Cho
3,4,*,
Hyun-Soo Kim
5,* and
Byung Seok Lee
2,3
1
Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Ulsan University Hospital, Ulsan 44033, Korea
2
Department of Obstetrics and Gynecology, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, Korea
3
Institute of Women’s Life Medical Science, Yonsei University College of Medicine, Seoul 03722, Korea
4
Department of Obstetrics and Gynecology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul 06273, Korea
5
Department of Pathology and Translational Genomics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(13), 3372; https://doi.org/10.3390/ijms20133372
Submission received: 22 June 2019 / Revised: 5 July 2019 / Accepted: 5 July 2019 / Published: 9 July 2019
(This article belongs to the Special Issue Endometriosis Research: From Bench to Bedside)
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Abstract

Estrogen affects endometrial cellular proliferation by regulating the expression of the c-myc gene. B-cell translocation gene 1 (BTG1), a translocation partner of the c-myc, is a tumor suppressor gene that promotes apoptosis and negatively regulates cellular proliferation and cell-to-cell adhesion. The aim of this study was to determine the role of BTG1 in the pathogenesis of endometriosis. BTG1 mRNA and protein expression was evaluated in eutopic and ectopic endometrium of 30 patients with endometriosis (endometriosis group), and in eutopic endometrium of 22 patients without endometriosis (control group). The effect of BTG1 downregulation on cellular migration, proliferation, and apoptosis was evaluated using transfection of primarily cultured human endometrial stromal cells (HESCs) with BTG1 siRNA. BTG1 mRNA expression level of eutopic and ectopic endometrium of endometriosis group were significantly lower than that of the eutopic endometrium of the control group. Migration and wound healing assays revealed that BTG1 downregulation resulted in a significant increase in migration potential of HESCs, characterized by increased expression of matrix metalloproteinase 2 (MMP2) and MMP9. Downregulation of BTG1 in HESCs significantly reduced Caspase 3 expression, indicating a decrease in apoptotic potential. In conclusion, our data suggest that downregulation of BTG1 plays an important role in the pathogenesis of endometriosis.
Keywords: BTG1; endometriosis; human endometrial stromal cells BTG1; endometriosis; human endometrial stromal cells

Share and Cite

MDPI and ACS Style

Kim, J.S.; Choi, Y.S.; Park, J.H.; Yun, J.; Kim, S.; Lee, J.H.; Yun, B.H.; Park, J.H.; Seo, S.K.; Cho, S.; et al. Role of B-Cell Translocation Gene 1 in the Pathogenesis of Endometriosis. Int. J. Mol. Sci. 2019, 20, 3372. https://doi.org/10.3390/ijms20133372

AMA Style

Kim JS, Choi YS, Park JH, Yun J, Kim S, Lee JH, Yun BH, Park JH, Seo SK, Cho S, et al. Role of B-Cell Translocation Gene 1 in the Pathogenesis of Endometriosis. International Journal of Molecular Sciences. 2019; 20(13):3372. https://doi.org/10.3390/ijms20133372

Chicago/Turabian Style

Kim, Jeong Sook, Young Sik Choi, Ji Hyun Park, Jisun Yun, Soohyun Kim, Jae Hoon Lee, Bo Hyon Yun, Joo Hyun Park, Seok Kyo Seo, SiHyun Cho, and et al. 2019. "Role of B-Cell Translocation Gene 1 in the Pathogenesis of Endometriosis" International Journal of Molecular Sciences 20, no. 13: 3372. https://doi.org/10.3390/ijms20133372

APA Style

Kim, J. S., Choi, Y. S., Park, J. H., Yun, J., Kim, S., Lee, J. H., Yun, B. H., Park, J. H., Seo, S. K., Cho, S., Kim, H.-S., & Lee, B. S. (2019). Role of B-Cell Translocation Gene 1 in the Pathogenesis of Endometriosis. International Journal of Molecular Sciences, 20(13), 3372. https://doi.org/10.3390/ijms20133372

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