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Int. J. Mol. Sci. 2018, 19(8), 2435; https://doi.org/10.3390/ijms19082435

Selected Molecular Mechanisms Involved in the Parasite–Host System Hymenolepis diminuta–Rattus norvegicus

1
Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Powstańców Wlkp. 72, 70-111 Szczecin, Poland
2
Department of Biology and Medical Parasitology, Pomeranian Medical University, Powstańców Wlkp. 72, 70-111 Szczecin, Poland
3
Department of Biochemistry and Human Nutrition, Pomeranian Medical University, Broniewskiego 24, 71-460 Szczecin, Poland
*
Author to whom correspondence should be addressed.
Received: 30 June 2018 / Revised: 2 August 2018 / Accepted: 15 August 2018 / Published: 17 August 2018
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
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Abstract

The rat tapeworm Hymenolepis diminuta is a parasite of the small intestine of rodents (mainly mice and rats), and accidentally humans. It is classified as a non-invasive tapeworm due to the lack of hooks on the tapeworm’s scolex, which could cause mechanical damage to host tissues. However, many studies have shown that metabolites secreted by H. diminuta interfere with the functioning of the host’s gastrointestinal tract, causing an increase in salivary secretion, suppression of gastric acid secretion, and an increase in the trypsin activity in the duodenum chyme. Our work presents the biochemical and molecular mechanisms of a parasite-host interaction, including the influence on ion transport and host intestinal microflora, morphology and biochemical parameters of blood, secretion of antioxidant enzymes, expression of Toll-like receptors, mechanisms of immune response, as well as the expression and activity of cyclooxygenases. We emphasize the interrelations between the parasite and the host at the cellular level resulting from the direct impact of the parasite as well as host defense reactions that lead to changes in the host’s tissues and organs. View Full-Text
Keywords: hymenolepidosis; molecular mechanisms; parasite–host system; rat hymenolepidosis; molecular mechanisms; parasite–host system; rat
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Kapczuk, P.; Kosik-Bogacka, D.; Łanocha-Arendarczyk, N.; Gutowska, I.; Kupnicka, P.; Chlubek, D.; Baranowska-Bosiacka, I. Selected Molecular Mechanisms Involved in the Parasite–Host System Hymenolepis diminuta–Rattus norvegicus. Int. J. Mol. Sci. 2018, 19, 2435.

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