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Open AccessArticle

Prenylated Flavonoids from Roots of Glycyrrhiza uralensis Induce Differentiation of B16-F10 Melanoma Cells

1
School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China
2
Division of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Hong Kong 999077, China
3
Shenzhen Key Laboratory of Edible and Medicinal Bioresources, The Hong Kong University of Science and Technology Shenzhen Research Institute, Hi-Tech Park, Shenzhen 518057, China
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(8), 2422; https://doi.org/10.3390/ijms19082422
Received: 12 July 2018 / Revised: 7 August 2018 / Accepted: 8 August 2018 / Published: 16 August 2018
(This article belongs to the Special Issue Plant Natural Products for Human Health)
Roots of Glycyrrhiza uralensis have been used as herbal medicine and natural sweetener. By activity-guided phytochemical investigation of the extracts from G. uralensis root, ten flavonoids, namely GF-1–GF-10, of which five were prenylated flavonoids, were found to show antiproliferative effects in melanoma B16-F10 cells. Three of the prenylated flavonoids, namely GF-1, GF-4 and GF-9, significantly induced the differentiation of B16-F10 cells; the inductions included increase of tyrosinase activity, tyrosinase protein, and melanin content. In GF-1 and GF-9 induced melanoma differentiation, the phosphorylation of p38 MAPK (mitogen activated potein kinase) was identified; while GF-4 could trigger the phosphorylation of PI3K/AKT (phosphatidylinositol 3-kinase/Protein Kinase B) signaling. However, application of GF-6 to the melanoma cells did not induce differentiation; but which promoted cell apoptotic signaling, i.e., increase levels of cleaved-PRAP, cleaved-caspase 3, and cleaved-caspase 9. These results suggested that different types of prenylated flavonoids from G. uralensis might have potential anticancer effects against melanoma cells by acting through different signaling pathways. View Full-Text
Keywords: Glycyrrhiza uralensis; prenylated flavonoids; antiproliferation; differentiation; melanoma cell Glycyrrhiza uralensis; prenylated flavonoids; antiproliferation; differentiation; melanoma cell
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MDPI and ACS Style

Zheng, Y.; Wang, H.; Yang, M.; Peng, G.; Dong, T.T.X.; Xu, M.L.; Tsim, K.W.K. Prenylated Flavonoids from Roots of Glycyrrhiza uralensis Induce Differentiation of B16-F10 Melanoma Cells. Int. J. Mol. Sci. 2018, 19, 2422.

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