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Int. J. Mol. Sci. 2018, 19(8), 2309; https://doi.org/10.3390/ijms19082309

Hydroxyl Radical-Suppressing Mechanism and Efficiency of Melanin-Mimetic Nanoparticles

1
Division of Materials Research, Institute of Materials and Systems for Sustainability, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan
2
Department of Biomaterials, Faculty of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-0044, Japan
*
Author to whom correspondence should be addressed.
Received: 12 June 2018 / Revised: 24 July 2018 / Accepted: 4 August 2018 / Published: 7 August 2018
(This article belongs to the Special Issue Cell-Biomaterial Interaction)
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Abstract

Harnessing melanins to scavenge free radicals in vivo may yield treatment methods for inflammatory disorders. Furthermore, elucidation of the mechanism underlying melanin-mediated suppression of free radicals, which is yet unclear, is warranted. Herein, we chemically synthesized melanin-mimetic nanoparticles (MeNPs) and investigated the mechanism underlying their use. MeNPs efficiently suppressed hydroxyl radicals by converting some MeNP hydroxyl groups to ketone groups. Furthermore, they suppressed hydroxyl radicals produced by lipopolysaccharide-treated Kupffer cells involved in hepatic cirrhosis pathogenesis, without causing significant cytotoxicity. The present results indicate the suitability of MeNPs to treat hepatic cirrhosis; however, further in vivo studies are warranted to determine their treatment efficacy. View Full-Text
Keywords: biomaterials; biomimetic; nanoparticles biomaterials; biomimetic; nanoparticles
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Hayashi, K.; Tokuda, A.; Sakamoto, W. Hydroxyl Radical-Suppressing Mechanism and Efficiency of Melanin-Mimetic Nanoparticles. Int. J. Mol. Sci. 2018, 19, 2309.

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