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The Making of Hematopoiesis: Developmental Ancestry and Environmental Nurture

1
Institute of Clinical Sciences, Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
2
Discipline of Physiology, College of Medicine & Nursing Health Science, National University of Ireland, Galway, Ireland
3
Developmental and Molecular Immunology, Department of Biomedicine, University of Basel, 4058 Basel, Switzerland
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(7), 2122; https://doi.org/10.3390/ijms19072122
Received: 10 July 2018 / Revised: 17 July 2018 / Accepted: 18 July 2018 / Published: 21 July 2018
Evidence from studies of the behaviour of stem and progenitor cells and of the influence of cytokines on their fate determination, has recently led to a revised view of the process by which hematopoietic stem cells and their progeny give rise to the many different types of blood and immune cells. The new scenario abandons the classical view of a rigidly demarcated lineage tree and replaces it with a much more continuum-like view of the spectrum of fate options open to hematopoietic stem cells and their progeny. This is in contrast to previous lineage diagrams, which envisaged stem cells progressing stepwise through a series of fairly-precisely described intermediate progenitors in order to close down alternative developmental options. Instead, stem and progenitor cells retain some capacity to step sideways and adopt alternative, closely related, fates, even after they have “made a lineage choice.” The stem and progenitor cells are more inherently versatile than previously thought and perhaps sensitive to lineage guidance by environmental cues. Here we examine the evidence that supports these views and reconsider the meaning of cell lineages in the context of a continuum model of stem cell fate determination and environmental modulation. View Full-Text
Keywords: blood and immune cells; cell lineage; cytokines; fate determination; hematopoiesis; stem cells blood and immune cells; cell lineage; cytokines; fate determination; hematopoiesis; stem cells
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MDPI and ACS Style

Brown, G.; Ceredig, R.; Tsapogas, P. The Making of Hematopoiesis: Developmental Ancestry and Environmental Nurture. Int. J. Mol. Sci. 2018, 19, 2122. https://doi.org/10.3390/ijms19072122

AMA Style

Brown G, Ceredig R, Tsapogas P. The Making of Hematopoiesis: Developmental Ancestry and Environmental Nurture. International Journal of Molecular Sciences. 2018; 19(7):2122. https://doi.org/10.3390/ijms19072122

Chicago/Turabian Style

Brown, Geoffrey, Rhodri Ceredig, and Panagiotis Tsapogas. 2018. "The Making of Hematopoiesis: Developmental Ancestry and Environmental Nurture" International Journal of Molecular Sciences 19, no. 7: 2122. https://doi.org/10.3390/ijms19072122

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