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Int. J. Mol. Sci. 2018, 19(2), 564;

Mitochondrial Dynamics in Basal and Stressful Conditions

Institut Necker-Enfants Malades (INEM), INSERM U1151-CNRS UMR 8253, Paris F-75014, France
Université Paris Descartes-Sorbonne Paris Cité, Paris F-75993, France
Author to whom correspondence should be addressed.
Received: 8 November 2017 / Revised: 30 January 2018 / Accepted: 7 February 2018 / Published: 13 February 2018
(This article belongs to the Special Issue Membrane Fusion)
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The historical role of mitochondria resides in converting the energy released during the oxidation of macromolecules (carbohydrates, lipids and proteins) into adenosine tri-phosphate, a major form of chemically stored energy which sustains cell growth and homeostasis. Beyond this role in bioenergetics regulation, mitochondria play a role in several other cellular processes including lipid metabolism, cellular calcium homeostasis, autophagy and immune responses. Furthermore, mitochondria are highly dynamic organelles: as all other cellular endomembranes, they are continuously moving along cytoskeleton, and, most importantly, they constantly interact one with each other by membrane tethering, fusion and fission. This review aims to highlight the tight correlation between the morphodynamics of mitochondria and their biological function(s), in physiological as well as stress conditions, in particular nutrient deprivation, pathogen attack and some human diseases. Finally, we emphasize some crosstalk between the fusion/fission machinery and the autophagy pathway to ending on some speculative hypothesis to inspire future research in the field. View Full-Text
Keywords: mitochondrial dynamics; autophagy; membranes mitochondrial dynamics; autophagy; membranes

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Zemirli, N.; Morel, E.; Molino, D. Mitochondrial Dynamics in Basal and Stressful Conditions. Int. J. Mol. Sci. 2018, 19, 564.

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