Next Article in Journal
Molecular-Assisted Pollen Grain Analysis Reveals Spatiotemporal Origin of Long-Distance Migrants of a Noctuid Moth
Next Article in Special Issue
Charged N-terminus of Influenza Fusion Peptide Facilitates Membrane Fusion
Previous Article in Journal
Sjögren-Like Lacrimal Keratoconjunctivitis in Germ-Free Mice
Previous Article in Special Issue
Peptide-Based Membrane Fusion Inhibitors Targeting HCoV-229E Spike Protein HR1 and HR2 Domains
Open AccessReview

Mitochondrial Dynamics in Basal and Stressful Conditions

by Naima Zemirli 1,2, Etienne Morel 1,2 and Diana Molino 1,2,*
1
Institut Necker-Enfants Malades (INEM), INSERM U1151-CNRS UMR 8253, Paris F-75014, France
2
Université Paris Descartes-Sorbonne Paris Cité, Paris F-75993, France
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(2), 564; https://doi.org/10.3390/ijms19020564
Received: 8 November 2017 / Revised: 30 January 2018 / Accepted: 7 February 2018 / Published: 13 February 2018
(This article belongs to the Special Issue Membrane Fusion)
The historical role of mitochondria resides in converting the energy released during the oxidation of macromolecules (carbohydrates, lipids and proteins) into adenosine tri-phosphate, a major form of chemically stored energy which sustains cell growth and homeostasis. Beyond this role in bioenergetics regulation, mitochondria play a role in several other cellular processes including lipid metabolism, cellular calcium homeostasis, autophagy and immune responses. Furthermore, mitochondria are highly dynamic organelles: as all other cellular endomembranes, they are continuously moving along cytoskeleton, and, most importantly, they constantly interact one with each other by membrane tethering, fusion and fission. This review aims to highlight the tight correlation between the morphodynamics of mitochondria and their biological function(s), in physiological as well as stress conditions, in particular nutrient deprivation, pathogen attack and some human diseases. Finally, we emphasize some crosstalk between the fusion/fission machinery and the autophagy pathway to ending on some speculative hypothesis to inspire future research in the field. View Full-Text
Keywords: mitochondrial dynamics; autophagy; membranes mitochondrial dynamics; autophagy; membranes
Show Figures

Graphical abstract

MDPI and ACS Style

Zemirli, N.; Morel, E.; Molino, D. Mitochondrial Dynamics in Basal and Stressful Conditions. Int. J. Mol. Sci. 2018, 19, 564.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop