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Open AccessArticle

Kaempferia parviflora Extract as a Potential Anti-Acne Agent with Anti-Inflammatory, Sebostatic and Anti-Propionibacterium acnes Activity

by 1 and 1,2,*
1
Department of Medical Science, College of Medical Science, SoonChunHyang University, 22 SoonChunHyang-ro, Asan, Chungnam 31538, Korea
2
Department of Medical Biotechnology, College of Medical Science, SoonChunHyang University, 22 SoonChunHyang-ro, Asan, Chungnam 31538, Korea
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(11), 3457; https://doi.org/10.3390/ijms19113457
Received: 12 October 2018 / Revised: 29 October 2018 / Accepted: 31 October 2018 / Published: 3 November 2018
(This article belongs to the Special Issue Natural Anti-Inflammatory Agents 2018)
Kaempferia parviflora, referred to as black ginger, has traditionally been used as a health-promoting alternative medicine. In this study, we examined the anti-inflammatory, sebostatic, and anti-Propionibacterium acnes activities of K. parviflora extract. The extract significantly down-regulated the expression of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2), and pro-inflammatory cytokine tumor necrosis factor alpha (TNF-α) level. Moreover, the phosphorylation of IĸBα and nuclear factor-kappa B (NF-κB), and the enhanced nuclear translocation of NF-κB p65 in lipopolysaccharide-stimulated murine macrophage-like cell line (RAW 264.7) cells were markedly decreased by the extract. Notably, the main component of K. parviflora, 5,7-dimethoxyflavone, also modulated the expression of iNOS and NF-κB signal molecules in P. acnes-stimulated human keratinocyte (HaCaT) cells. Additionally, K. parviflora extract inhibited the lipogenesis of sebocytes, as evidenced by a reduced level of triglyceride and lipid accumulation in the sebocytes. The sebostatic effect was also confirmed by a reduced expression of peroxisome proliferation-activating receptors (PPAR-γ) and oil-red O staining in sebocytes. Taken together, this study suggests for the first time that K. parviflora extract could be developed as a potential natural anti-acne agent with anti-inflammatory, sebostatic, and anti-P. acnes activity. View Full-Text
Keywords: Kaempferia parviflora; anti-inflammation; sebostatic effect; anti-P. acnes effect Kaempferia parviflora; anti-inflammation; sebostatic effect; anti-P. acnes effect
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MDPI and ACS Style

Jin, S.; Lee, M.-Y. Kaempferia parviflora Extract as a Potential Anti-Acne Agent with Anti-Inflammatory, Sebostatic and Anti-Propionibacterium acnes Activity. Int. J. Mol. Sci. 2018, 19, 3457. https://doi.org/10.3390/ijms19113457

AMA Style

Jin S, Lee M-Y. Kaempferia parviflora Extract as a Potential Anti-Acne Agent with Anti-Inflammatory, Sebostatic and Anti-Propionibacterium acnes Activity. International Journal of Molecular Sciences. 2018; 19(11):3457. https://doi.org/10.3390/ijms19113457

Chicago/Turabian Style

Jin, Solee; Lee, Mi-Young. 2018. "Kaempferia parviflora Extract as a Potential Anti-Acne Agent with Anti-Inflammatory, Sebostatic and Anti-Propionibacterium acnes Activity" Int. J. Mol. Sci. 19, no. 11: 3457. https://doi.org/10.3390/ijms19113457

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