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Int. J. Mol. Sci. 2018, 19(10), 3139; https://doi.org/10.3390/ijms19103139

MicroRNAs in Autoimmunity and Hematological Malignancies

1
Ageing Research Center and Translational medicine-CeSI-MeT, 66100 Chieti, Italy
2
Department of Medical, Oral and Biotechnological Sciences (DSMOB), “G. d’Annunzio” University Chieti-Pescara, 66100 Chieti, Italy
3
Harvard Medical School Initiative for RNA Medicine, Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
4
Department of Medicine and Aging Science (DMSI), “G. d’Annunzio” University Chieti-Pescara, 66100 Chieti, Italy
*
Author to whom correspondence should be addressed.
Received: 26 September 2018 / Accepted: 2 October 2018 / Published: 12 October 2018
(This article belongs to the Special Issue The Role of MicroRNAs in Human Diseases)
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Abstract

Autoimmunity and hematological malignancies are often concomitant in patients. A causal bidirectional relationship exists between them. Loss of immunological tolerance with inappropriate activation of the immune system, likely due to environmental and genetic factors, can represent a breeding ground for the appearance of cancer cells and, on the other hand, blood cancers are characterized by imbalanced immune cell subsets that could support the development of the autoimmune clone. Considerable effort has been made for understanding the proteins that have a relevant role in both processes; however, literature advances demonstrate that microRNAs (miRNAs) surface as the epigenetic regulators of those proteins and control networks linked to both autoimmunity and hematological malignancies. Here we review the most up-to-date findings regarding the miRNA-based molecular mechanisms that underpin autoimmunity and hematological malignancies. View Full-Text
Keywords: autoimmunity; leukemia; lymphoma; microRNAs autoimmunity; leukemia; lymphoma; microRNAs
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Marco, M.D.; Ramassone, A.; Pagotto, S.; Anastasiadou, E.; Veronese, A.; Visone, R. MicroRNAs in Autoimmunity and Hematological Malignancies. Int. J. Mol. Sci. 2018, 19, 3139.

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