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Review

Maternal Macronutrient Consumption and the Developmental Origins of Metabolic Disease in the Offspring

1
Department of Pharmacology & Therapeutics, University of Manitoba, Winnipeg, MB R3E 3P4, Canada
2
Diabetes Research Envisioned and Accomplished in Manitoba (DREAM) Research Theme of the Children’s Hospital Research Institute of Manitoba, University of Manitoba, Winnipeg, MB R3E 3P4, Canada
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2017, 18(7), 1451; https://doi.org/10.3390/ijms18071451
Received: 8 March 2017 / Revised: 14 June 2017 / Accepted: 30 June 2017 / Published: 6 July 2017
(This article belongs to the Special Issue Nutrigenomics of Risk Factors for Disease)
Recent research aimed at understanding the rise in obesity and cardiometabolic disease in children suggests that suboptimal maternal nutrition conditions organ systems and physiological responses in the offspring contributing to disease development. Understanding the mechanisms by which the macronutrient composition of the maternal diet during pregnancy or lactation affects health outcomes in the offspring may lead to new maternal nutrition recommendations, disease prevention strategies and therapies that reduce the increasing incidence of cardiometabolic disease in children. Recent mechanistic animal model research has identified how excess fats and sugars in the maternal diet alter offspring glucose tolerance, insulin signaling and metabolism. Maternal nutrition appears to influence epigenetic alterations in the offspring and the programming of gene expression in key metabolic pathways. This review is focused on experimental studies in animal models that have investigated mechanisms of how maternal consumption of macronutrients affects cardiometabolic disease development in the offspring. Future research using “-omic” technologies is essential to elucidate the mechanisms of how altered maternal macronutrient consumption influences the development of disease in the offspring. View Full-Text
Keywords: developmental programming; metabolic disease; cardiovascular disease; high-fat diet; sucrose developmental programming; metabolic disease; cardiovascular disease; high-fat diet; sucrose
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MDPI and ACS Style

Kereliuk, S.M.; Brawerman, G.M.; Dolinsky, V.W. Maternal Macronutrient Consumption and the Developmental Origins of Metabolic Disease in the Offspring. Int. J. Mol. Sci. 2017, 18, 1451. https://doi.org/10.3390/ijms18071451

AMA Style

Kereliuk SM, Brawerman GM, Dolinsky VW. Maternal Macronutrient Consumption and the Developmental Origins of Metabolic Disease in the Offspring. International Journal of Molecular Sciences. 2017; 18(7):1451. https://doi.org/10.3390/ijms18071451

Chicago/Turabian Style

Kereliuk, Stephanie M., Gabriel M. Brawerman, and Vernon W. Dolinsky 2017. "Maternal Macronutrient Consumption and the Developmental Origins of Metabolic Disease in the Offspring" International Journal of Molecular Sciences 18, no. 7: 1451. https://doi.org/10.3390/ijms18071451

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