Role of Hormones in the Regulation of RACK1 Expression as a Signaling Checkpoint in Immunosenescence
Abstract
:1. Introduction
2. The Critical Involvement of Hormonal Balance Affecting RACK1 Expression
3. RACK1 and Its Transcriptional Regulation
3.1. RACK1: A Versatile Hub of Different Signaling Pathways
3.2. The RACK1 Promoter Element and Its Transcription Factor Binding Sites
3.3. RACK1 and Its Glucocorticoid Regulation
4. DHEA and Cortisol in the Regulation of GR Isoforms
5. Effect of Androgens in DHEA-Induced RACK1 Expression
6. Conclusions
Acknowledgments
Conflicts of Interest
Abbreviations
RACK1 | Receptor for Activated C Kinase1 |
DHEA | Dehydroepiandrosterone |
PKC | Protein Kinase C |
AD | Alzheimer’s disease |
GRE | Glucocorticoid responsive element |
AR | Androgen receptor |
GR | Glucocorticoid receptor |
EDC | Endocrine disrupting chemicals |
LPS | Lipopolysaccharide |
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Racchi, M.; Buoso, E.; Ronfani, M.; Serafini, M.M.; Galasso, M.; Lanni, C.; Corsini, E. Role of Hormones in the Regulation of RACK1 Expression as a Signaling Checkpoint in Immunosenescence. Int. J. Mol. Sci. 2017, 18, 1453. https://doi.org/10.3390/ijms18071453
Racchi M, Buoso E, Ronfani M, Serafini MM, Galasso M, Lanni C, Corsini E. Role of Hormones in the Regulation of RACK1 Expression as a Signaling Checkpoint in Immunosenescence. International Journal of Molecular Sciences. 2017; 18(7):1453. https://doi.org/10.3390/ijms18071453
Chicago/Turabian StyleRacchi, Marco, Erica Buoso, Melania Ronfani, Melania M. Serafini, Marilisa Galasso, Cristina Lanni, and Emanuela Corsini. 2017. "Role of Hormones in the Regulation of RACK1 Expression as a Signaling Checkpoint in Immunosenescence" International Journal of Molecular Sciences 18, no. 7: 1453. https://doi.org/10.3390/ijms18071453