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Int. J. Mol. Sci. 2017, 18(5), 967;

Studies on Trans-Resveratrol/Carboxymethylated (1,3/1,6)-β-d-Glucan Association for Aerosol Pharmaceutical Applications

Department of Biochemical Sciences, “Sapienza” University of Rome, Piazzale Aldo Moro, 5, 00185 Roma, Italy
QI Technologies, Via Monte D’Oro 2/A, Pomezia, 00071 Rome, Italy
Department of Public Health and Infectious Diseases, “Sapienza” University of Rome, Piazzale Aldo Moro, 5, 00185 Roma, Italy
Author to whom correspondence should be addressed.
Academic Editor: Vaclav Vetvicka
Received: 21 March 2017 / Revised: 20 April 2017 / Accepted: 30 April 2017 / Published: 3 May 2017
(This article belongs to the Special Issue Glucan: New Perspectives on Biochemistry and Application)
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A resveratrol/carboxymethylated glucan (CM-glucan) combination is known to inhibit rhinovirus replication and expression of inflammatory mediators in nasal epithelia. The aim of this study was to develop an aerosol formulation containing an association of the two molecules which could reach the lower respiratory tract. Mass median aerodynamic diameter (MMAD) of a resveratrol/CM-glucan combination was lower than that shown by resveratrol or CM-glucan alone (2.83 versus 3.28 and 2.96 µm, respectively). The resveratrol/CM-glucan association results in the finest and most monodispersed particles in comparison to the two single components. The association also evidenced lower values for all particle size distribution parameters, suggesting that the pharmacological synergy observed in previous studies may be accompanied by a pharmaceutical one. Moreover, we showed that the CM-glucan matrix did not exert an inhibitory effect on resveratrol nebulization, demonstrating the good suitability of these two molecules in association for simultaneous aerosol volatilization. View Full-Text
Keywords: aerosol; resveratrol; carboxymethylated glucan; MMAD aerosol; resveratrol; carboxymethylated glucan; MMAD

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Francioso, A.; Cossi, R.; Fanelli, S.; Mastromarino, P.; Mosca, L. Studies on Trans-Resveratrol/Carboxymethylated (1,3/1,6)-β-d-Glucan Association for Aerosol Pharmaceutical Applications. Int. J. Mol. Sci. 2017, 18, 967.

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