We would like to make a clarification to our article [1] entitled “The Regulations of Deubiquitinase USP15 and Its Pathophysiological Mechanisms in Diseases”. We regret that cited reference 26 [2] in the paper has been retracted [3]. Luna-Vargas et al., retracted the paper because they could not reproduce the results of lower Km for the USP4 catalytic domain under their described conditions [2]. Despite their article withdrawal, they emphasized that the USP4 crystal structure and the ubiquitin-binding data in [2] are not in question. To avoid any confusion of the readers, we have replaced the above reference with a new reference [4] and rephrased the statement in the article. We would like to apologize for any inconvenience caused.
The manuscript will be updated, and the original will remain online at the article webpage.
References
- Chou, C.-K.; Chang, Y.-T.; Korinek, M.; Chen, Y.-T.; Yang, Y.-T.; Leu, S.; Lin, I.-L.; Tang, C.-J.; Chiu, C.-C. The regulations of deubiquitinase USP15 and its pathophysiological mechanisms in diseases. Int. J. Mol. Sci. 2017, 18, 483. [Google Scholar] [CrossRef] [PubMed]
- Luna-Vargas, M.P.; Faesen, A.C.; van Dijk, W.J.; Rape, M.; Fish, A.; Sixma, T.K. Ubiquitin-specific protease 4 is inhibited by its ubiquitin-like domain. EMBO Rep. 2011, 12, 365–372. [Google Scholar] [CrossRef] [PubMed]
- Retraction: “Ubiquitin-specific protease 4 is inhibited by its ubiquitin-like domain” by MP Luna-Vargas, AC Faesen, WJ van Dijk, M Rape, A Fish, TK Sixma. EMBO Rep. 2014, 15, 121.
- Clerici, M.; Luna-Vargas, M.P.; Faesen, A.C.; Sixma, T.K. The DUSP-Ubl domain of USP4 enhances its catalytic efficiency by promoting ubiquitin exchange. Nat. Commun. 2014, 5, 5399. [Google Scholar] [CrossRef] [PubMed]
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