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Int. J. Mol. Sci. 2017, 18(11), 2464; https://doi.org/10.3390/ijms18112464

Green Routes for the Production of Enantiopure Benzylisoquinoline Alkaloids

1
Center for Life Nano [email protected], Istituto Italiano di Tecnologia, Viale Regina Elena 291, 00161 Rome, Italy
2
Deaprtment of Biochemical Sciences “A.Rossi Fanelli”, Sapienza University of Rome, Pizzale Aldo Moro 5, 00185 Rome, Italy
3
Department of Chemistry and Technology of Drugs, Sapienza University of Rome, Pizzale Aldo Moro 5, 00185 Rome, Italy
*
Authors to whom correspondence should be addressed.
Received: 6 November 2017 / Revised: 14 November 2017 / Accepted: 16 November 2017 / Published: 20 November 2017
(This article belongs to the Special Issue Molecular Transformations of Natural Products)
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Abstract

Benzylisoquinoline alkaloids (BIAs) are among the most important plant secondary metabolites, in that they include a number of biologically active substances widely employed as pharmaceuticals. Isolation of BIAs from their natural sources is an expensive and time-consuming procedure as they accumulate in very low levels in plant. Moreover, total synthesis is challenging due to the presence of stereogenic centers. In view of these considerations, green and scalable methods for BIA synthesis using fully enzymatic approaches are getting more and more attention. The aim of this paper is to review fully enzymatic strategies for producing the benzylisoquinoline central precursor, (S)-norcoclaurine and its derivatives. Specifically, we will detail the current status of synthesis of BIAs in microbial hosts as well as using isolated and recombinant enzymes. View Full-Text
Keywords: alkaloids; benzylisoquinoline alkaloids; green synthesis; recombinant enzymes; microbial factories alkaloids; benzylisoquinoline alkaloids; green synthesis; recombinant enzymes; microbial factories
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Ghirga, F.; Bonamore, A.; Calisti, L.; D’Acquarica, I.; Mori, M.; Botta, B.; Boffi, A.; Macone, A. Green Routes for the Production of Enantiopure Benzylisoquinoline Alkaloids. Int. J. Mol. Sci. 2017, 18, 2464.

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