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Int. J. Mol. Sci. 2016, 17(6), 915;

The Interactions of CPP–ACP with Saliva

Oral Health Cooperative Research Centre, Melbourne Dental School, Bio21 Institute, The University of Melbourne, 720 Swanston Street, Melbourne 3010, Australia
Author to whom correspondence should be addressed.
Academic Editor: Eva Freisinger
Received: 14 March 2016 / Revised: 6 May 2016 / Accepted: 24 May 2016 / Published: 9 June 2016
(This article belongs to the Special Issue Applied Bioinorganic Chemistry and Selected Papers from 13th ISABC)
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The repair of early dental caries lesions has been demonstrated by the application of the remineralisation technology based on casein phosphopeptide-stabilised amorphous calcium phosphate complexes (CPP–ACP). These complexes consist of an amorphous calcium phosphate mineral phase stabilised and encapsulated by the self-assembly of milk-derived phosphopeptides. During topical application of CPP–ACP complexes in the oral cavity, the CPP encounters the enamel pellicle consisting of salivary proteins and peptides. However the interactions of the CPP with the enamel salivary pellicle are not known. The studies presented here reveal that the predominant peptides of CPP–ACP complexes do interact with specific salivary proteins and peptides of the enamel pellicle, and provide a mechanism by which the CPP–ACP complexes are localised at the tooth surface to promote remineralisation. View Full-Text
Keywords: saliva; pellicle; casein phosphopeptide; enamel saliva; pellicle; casein phosphopeptide; enamel

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Huq, N.L.; Myroforidis, H.; Cross, K.J.; Stanton, D.P.; Veith, P.D.; Ward, B.R.; Reynolds, E.C. The Interactions of CPP–ACP with Saliva. Int. J. Mol. Sci. 2016, 17, 915.

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