Next Article in Journal
Genome-Wide Mapping of Growth-Related Quantitative Trait Loci in Orange-Spotted Grouper (Epinephelus coioides) Using Double Digest Restriction-Site Associated DNA Sequencing (ddRADseq)
Next Article in Special Issue
GL-1196 Suppresses the Proliferation and Invasion of Gastric Cancer Cells via Targeting PAK4 and Inhibiting PAK4-Mediated Signaling Pathways
Previous Article in Journal
Power Frequency Magnetic Fields Affect the p38 MAPK-Mediated Regulation of NB69 Cell Proliferation Implication of Free Radicals
Previous Article in Special Issue
Molecular Insight into Gut Microbiota and Rheumatoid Arthritis
Open AccessReview

Present Advances and Future Perspectives of Molecular Targeted Therapy for Osteosarcoma

1
Institute for Advancing Translational Medicine in Bone & Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong 999077, China
2
Department of Orthopaedic Surgery, Shenzhen Hospital, Southern Medical University, Shenzhen 518100, China
3
Orthopaedic Surgery Department, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
4
Department of Orthopaedic Surgery, the First Hospital of Huizhou, Huizhou 516000, China
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Hailong Zhu
Int. J. Mol. Sci. 2016, 17(4), 506; https://doi.org/10.3390/ijms17040506
Received: 27 February 2016 / Accepted: 30 March 2016 / Published: 6 April 2016
(This article belongs to the Special Issue Translational Molecular Medicine & Molecular Drug Discovery)
Osteosarcoma (OS) is a bone cancer mostly occurring in pediatric population. Current treatment regime of surgery and intensive chemotherapy could cure about 60%–75% patients with primary osteosarcoma, however only 15% to 30% can be cured when pulmonary metastasis or relapse has taken place. Hence, novel precise OS-targeting therapies are being developed with the hope of addressing this issue. This review summarizes the current development of molecular mechanisms and targets for osteosarcoma. Therapies that target these mechanisms with updated information on clinical trials are also reviewed. Meanwhile, we further discuss novel therapeutic targets and OS-targeting drug delivery systems. In conclusion, a full insight in OS pathogenesis and OS-targeting strategies would help us explore novel targeted therapies for metastatic osteosarcoma. View Full-Text
Keywords: osteosarcoma; molecular targets; targeted therapy; molecular mechanism osteosarcoma; molecular targets; targeted therapy; molecular mechanism
Show Figures

Figure 1

MDPI and ACS Style

Shaikh, A.B.; Li, F.; Li, M.; He, B.; He, X.; Chen, G.; Guo, B.; Li, D.; Jiang, F.; Dang, L.; Zheng, S.; Liang, C.; Liu, J.; Lu, C.; Liu, B.; Lu, J.; Wang, L.; Lu, A.; Zhang, G. Present Advances and Future Perspectives of Molecular Targeted Therapy for Osteosarcoma. Int. J. Mol. Sci. 2016, 17, 506.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop