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Int. J. Mol. Sci. 2016, 17(4), 506;

Present Advances and Future Perspectives of Molecular Targeted Therapy for Osteosarcoma

Institute for Advancing Translational Medicine in Bone & Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong 999077, China
Department of Orthopaedic Surgery, Shenzhen Hospital, Southern Medical University, Shenzhen 518100, China
Orthopaedic Surgery Department, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
Department of Orthopaedic Surgery, the First Hospital of Huizhou, Huizhou 516000, China
These authors contributed equally to this work.
Authors to whom correspondence should be addressed.
Academic Editor: Hailong Zhu
Received: 27 February 2016 / Accepted: 30 March 2016 / Published: 6 April 2016
(This article belongs to the Special Issue Translational Molecular Medicine & Molecular Drug Discovery)
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Osteosarcoma (OS) is a bone cancer mostly occurring in pediatric population. Current treatment regime of surgery and intensive chemotherapy could cure about 60%–75% patients with primary osteosarcoma, however only 15% to 30% can be cured when pulmonary metastasis or relapse has taken place. Hence, novel precise OS-targeting therapies are being developed with the hope of addressing this issue. This review summarizes the current development of molecular mechanisms and targets for osteosarcoma. Therapies that target these mechanisms with updated information on clinical trials are also reviewed. Meanwhile, we further discuss novel therapeutic targets and OS-targeting drug delivery systems. In conclusion, a full insight in OS pathogenesis and OS-targeting strategies would help us explore novel targeted therapies for metastatic osteosarcoma. View Full-Text
Keywords: osteosarcoma; molecular targets; targeted therapy; molecular mechanism osteosarcoma; molecular targets; targeted therapy; molecular mechanism

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Shaikh, A.B.; Li, F.; Li, M.; He, B.; He, X.; Chen, G.; Guo, B.; Li, D.; Jiang, F.; Dang, L.; Zheng, S.; Liang, C.; Liu, J.; Lu, C.; Liu, B.; Lu, J.; Wang, L.; Lu, A.; Zhang, G. Present Advances and Future Perspectives of Molecular Targeted Therapy for Osteosarcoma. Int. J. Mol. Sci. 2016, 17, 506.

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