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Open AccessReview

Roles of B Cell-Intrinsic TLR Signals in Systemic Lupus Erythematosus

1
Department of Pathology and Center of Infection and Immunology, Shenzhen Institute of Research and Innovation, The University of Hong Kong, Hong Kong, China
2
Department of Rheumatology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Chak-Sing Lau
Int. J. Mol. Sci. 2015, 16(6), 13084-13105; https://doi.org/10.3390/ijms160613084
Received: 27 April 2015 / Revised: 31 May 2015 / Accepted: 3 June 2015 / Published: 9 June 2015
Toll-like receptors (TLRs) are a large family of pattern recognition receptors. TLR signals are involved in the pathogenesis of systemic lupus erythematosus. Mouse and human B cells constitutively express most TLRs. Many B cell subpopulations are highly responsive to certain TLR ligation, including B-1 B cells, transitional B cells, marginal zone B cells, germinal center B cell and memory B cells. The B cell-intrinsic TLR signals play critical roles during lupus process. In this review, roles of B cell-intrinsic TLR2, 4, 7, 8 and 9 signals are discussed during lupus pathogenesis in both mouse model and patients. Moreover, mechanisms underlying TLR ligation-triggered B cell activation and signaling pathways are highlighted. View Full-Text
Keywords: toll-like receptor (TLR); systemic lupus erythematosus (SLE); anti-nuclear autoantibody (ANA); B-1 B cells; transitional B cells; marginal zone B cells (MZ B cells); germinal center B cells (GC B cells); memory B cells; myeloid differentiation primary response gene 88 (MyD88); Unc-93 Homolog B1 (C. elegans) (Unc93b1) toll-like receptor (TLR); systemic lupus erythematosus (SLE); anti-nuclear autoantibody (ANA); B-1 B cells; transitional B cells; marginal zone B cells (MZ B cells); germinal center B cells (GC B cells); memory B cells; myeloid differentiation primary response gene 88 (MyD88); Unc-93 Homolog B1 (C. elegans) (Unc93b1)
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Ma, K.; Li, J.; Fang, Y.; Lu, L. Roles of B Cell-Intrinsic TLR Signals in Systemic Lupus Erythematosus. Int. J. Mol. Sci. 2015, 16, 13084-13105.

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