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Int. J. Mol. Sci. 2015, 16(3), 4615-4627;

Methods for Biomimetic Remineralization of Human Dentine: A Systematic Review

Faculty of Dentistry, The University of Hong Kong, Hong Kong, China
Key Laboratory of Oral Diseases Research of Anhui Province, Stomatological Hospital & College, Anhui Medical University, Hefei 230032, China
Author to whom correspondence should be addressed.
Academic Editor: Mohamed N. Rahaman
Received: 9 January 2015 / Revised: 6 February 2015 / Accepted: 16 February 2015 / Published: 2 March 2015
(This article belongs to the Special Issue Biomaterials for Tissue Engineering)
Full-Text   |   PDF [725 KB, uploaded 2 March 2015]   |  


This study aimed to review the laboratory methods on biomimetic remineralization of demineralized human dentine. A systematic search of the publications in the PubMed, TRIP, and Web of Science databases was performed. Titles and abstracts of initially identified publications were screened. Clinical trials, reviews, non-English articles, resin-dentine interface studies, hybrid layer studies, hybrid scaffolds studies, and irrelevant studies were excluded. The remaining papers were retrieved with full texts. Manual screening was conducted on the bibliographies of remaining papers to identify relevant articles. A total of 716 studies were found, and 690 were excluded after initial screening. Two articles were identified from the bibliographies of the remaining papers. After retrieving the full text, 23 were included in this systematic review. Sixteen studies used analogues to mimic the functions of non-collagenous proteins in biomineralization of dentine, and four studies used bioactive materials to induce apatite formation on demineralized dentine surface. One study used zinc as a bioactive element, one study used polydopamine, and another study constructed an agarose hydrogel system for biomimetic mineralization of dentine. Many studies reported success in biomimetic mineralization of dentine, including the use of non-collagenous protein analogues, bioactive materials, or elements and agarose hydrogel system. View Full-Text
Keywords: biomimetic; remineralization; dentine; non-collagenous proteins biomimetic; remineralization; dentine; non-collagenous proteins

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Cao, C.Y.; Mei, M.L.; Li, Q.-L.; Lo, E.C.M.; Chu, C.H. Methods for Biomimetic Remineralization of Human Dentine: A Systematic Review. Int. J. Mol. Sci. 2015, 16, 4615-4627.

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