Next Article in Journal
Chloroplast-Expressed MSI-99 in Tobacco Improves Disease Resistance and Displays Inhibitory Effect against Rice Blast Fungus
Next Article in Special Issue
Three-Dimensional Cell Culture: A Breakthrough in Vivo
Previous Article in Journal
Nitric Oxide and Reactive Oxygen Species in the Pathogenesis of Preeclampsia
Previous Article in Special Issue
Effect of Platelet-Rich Plasma and Bioactive Glass Powder for the Improvement of Rotator Cuff Tendon-to-Bone Healing in a Rabbit Model
Open AccessReview

Methods for Biomimetic Remineralization of Human Dentine: A Systematic Review

Faculty of Dentistry, The University of Hong Kong, Hong Kong, China
Key Laboratory of Oral Diseases Research of Anhui Province, Stomatological Hospital & College, Anhui Medical University, Hefei 230032, China
Author to whom correspondence should be addressed.
Academic Editor: Mohamed N. Rahaman
Int. J. Mol. Sci. 2015, 16(3), 4615-4627;
Received: 9 January 2015 / Revised: 6 February 2015 / Accepted: 16 February 2015 / Published: 2 March 2015
(This article belongs to the Special Issue Biomaterials for Tissue Engineering)
This study aimed to review the laboratory methods on biomimetic remineralization of demineralized human dentine. A systematic search of the publications in the PubMed, TRIP, and Web of Science databases was performed. Titles and abstracts of initially identified publications were screened. Clinical trials, reviews, non-English articles, resin-dentine interface studies, hybrid layer studies, hybrid scaffolds studies, and irrelevant studies were excluded. The remaining papers were retrieved with full texts. Manual screening was conducted on the bibliographies of remaining papers to identify relevant articles. A total of 716 studies were found, and 690 were excluded after initial screening. Two articles were identified from the bibliographies of the remaining papers. After retrieving the full text, 23 were included in this systematic review. Sixteen studies used analogues to mimic the functions of non-collagenous proteins in biomineralization of dentine, and four studies used bioactive materials to induce apatite formation on demineralized dentine surface. One study used zinc as a bioactive element, one study used polydopamine, and another study constructed an agarose hydrogel system for biomimetic mineralization of dentine. Many studies reported success in biomimetic mineralization of dentine, including the use of non-collagenous protein analogues, bioactive materials, or elements and agarose hydrogel system. View Full-Text
Keywords: biomimetic; remineralization; dentine; non-collagenous proteins biomimetic; remineralization; dentine; non-collagenous proteins
Show Figures

Figure 1

MDPI and ACS Style

Cao, C.Y.; Mei, M.L.; Li, Q.-L.; Lo, E.C.M.; Chu, C.H. Methods for Biomimetic Remineralization of Human Dentine: A Systematic Review. Int. J. Mol. Sci. 2015, 16, 4615-4627.

Show more citation formats Show less citations formats

Article Access Map by Country/Region

Only visits after 24 November 2015 are recorded.
Search more from Scilit
Back to TopTop