Current Status of Photodynamic Therapy in Digestive Tract Carcinoma in Japan
by
Atsushi Nanashima *,† and Takeshi Nagayasu †
Atsushi Nanashima *,† and Takeshi Nagayasu †
Department of Surgical Oncology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1, Sakamoto, Nagasaki 852-8501, Japan
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Academic Editor: Michael R. Hamblin
Int. J. Mol. Sci. 2015, 16(2), 3434-3440; https://doi.org/10.3390/ijms16023434
Received: 15 December 2014 / Revised: 15 January 2015 / Accepted: 30 January 2015 / Published: 4 February 2015
(This article belongs to the Special Issue Advances in Photodynamic Therapy)
Photodynamic therapy (PDT) is an effective local treatment modality as a cancer-specific laser ablation in malignancy of some organs including digestive tracts or bile duct. In Japan, PDT has been applied at the early period after the first clinical induction in 1980’s. Although the useful efficacy was clarified, PDT has not been fully applied because of the phototoxicity of the porfimer sodium. The next generated talaporfin-sodium was used for PDT, in which phototoxicity was reduced and, however, the clinical efficacy for digestive tract malignancy has not yet been clarified. By proceeding the experimental and clinical trials, it is necessary to clarify the evidence of efficacy as a local powerful treatment with the conventional surgery, brachiotherapy and chemotherapy in the future step.
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Keywords:
photodynamic therapy; digestive tract cancer; bile duct carcinoma; porfimer sodium; talaporfin sodium; Japan
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MDPI and ACS Style
Nanashima, A.; Nagayasu, T. Current Status of Photodynamic Therapy in Digestive Tract Carcinoma in Japan. Int. J. Mol. Sci. 2015, 16, 3434-3440.
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