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Int. J. Mol. Sci. 2015, 16(2), 2851-2863;

Interleukin-27 in T Cell Immunity

Department of Allergy and Rheumatology, Graduate School of Medicine, the University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
Max Planck-The University of Tokyo Center for Integrative Inflammology, the University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8505, Japan
Author to whom correspondence should be addressed.
Academic Editor: Kamal D. Moudgil
Received: 27 December 2014 / Revised: 19 January 2015 / Accepted: 22 January 2015 / Published: 27 January 2015
(This article belongs to the Special Issue Mechanism of Action and Applications of Cytokines in Immunotherapy)
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Interleukin (IL)-27, a member of IL-12/IL-23 heterodimeric family of cytokines, has pleiotropic properties that can enhance or limit immune responses. IL-27 acts on various cell types, including T cells, B cells, macrophages, dendritic cells, natural killer (NK) cells and non-hematopoietic cells. Intensive studies have been conducted especially on T cells, revealing that various subsets of T cells respond uniquely to IL-27. IL-27 induces expansion of Th1 cells by activating signal transducer and activator of transcription (STAT) 1-mediated T-bet signaling pathway. On the other hand, IL-27 suppresses immune responses through inhibition of the development of T helper (Th) 17 cells and induction of IL-10 production in a STAT1- and STAT3-dependent manner. IL-27 is a potentially promising cytokine for therapeutic approaches on various human diseases. Here, we provide an overview of the biology of IL-27 related to T cell subsets, its structure, and production mechanism. View Full-Text
Keywords: IL-27; IL-27p28; Ebi3; T cell subset IL-27; IL-27p28; Ebi3; T cell subset

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Iwasaki, Y.; Fujio, K.; Okamura, T.; Yamamoto, K. Interleukin-27 in T Cell Immunity. Int. J. Mol. Sci. 2015, 16, 2851-2863.

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