Interleukin-27 in T Cell Immunity
AbstractInterleukin (IL)-27, a member of IL-12/IL-23 heterodimeric family of cytokines, has pleiotropic properties that can enhance or limit immune responses. IL-27 acts on various cell types, including T cells, B cells, macrophages, dendritic cells, natural killer (NK) cells and non-hematopoietic cells. Intensive studies have been conducted especially on T cells, revealing that various subsets of T cells respond uniquely to IL-27. IL-27 induces expansion of Th1 cells by activating signal transducer and activator of transcription (STAT) 1-mediated T-bet signaling pathway. On the other hand, IL-27 suppresses immune responses through inhibition of the development of T helper (Th) 17 cells and induction of IL-10 production in a STAT1- and STAT3-dependent manner. IL-27 is a potentially promising cytokine for therapeutic approaches on various human diseases. Here, we provide an overview of the biology of IL-27 related to T cell subsets, its structure, and production mechanism. View Full-Text
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Iwasaki, Y.; Fujio, K.; Okamura, T.; Yamamoto, K. Interleukin-27 in T Cell Immunity. Int. J. Mol. Sci. 2015, 16, 2851-2863.
Iwasaki Y, Fujio K, Okamura T, Yamamoto K. Interleukin-27 in T Cell Immunity. International Journal of Molecular Sciences. 2015; 16(2):2851-2863.Chicago/Turabian Style
Iwasaki, Yukiko; Fujio, Keishi; Okamura, Tomohisa; Yamamoto, Kazuhiko. 2015. "Interleukin-27 in T Cell Immunity." Int. J. Mol. Sci. 16, no. 2: 2851-2863.