Next Article in Journal
A Combined Experimental and Computational Study of Vam3, a Derivative of Resveratrol, and Syk Interaction
Next Article in Special Issue
DNA and RNA Quadruplex-Binding Proteins
Previous Article in Journal
Defining Molecular Sensors to Assess Long-Term Effects of Pesticides on Carcinogenesis
Previous Article in Special Issue
What Controls DNA Looping?
Article Menu
Issue 9 (September) cover image

Export Article

Open AccessReview
Int. J. Mol. Sci. 2014, 15(9), 17162-17187;

Chromatin Structure and Dynamics in Hot Environments: Architectural Proteins and DNA Topoisomerases of Thermophilic Archaea

Institute of Biosciences and Bioresources, National Research Council of Italy, Naples 80131, Italy
Author to whom correspondence should be addressed.
Received: 22 July 2014 / Revised: 19 August 2014 / Accepted: 9 September 2014 / Published: 25 September 2014
(This article belongs to the Special Issue Identification and Roles of the Structure of DNA)
Full-Text   |   PDF [1072 KB, uploaded 25 September 2014]   |  


In all organisms of the three living domains (Bacteria, Archaea, Eucarya) chromosome-associated proteins play a key role in genome functional organization. They not only compact and shape the genome structure, but also regulate its dynamics, which is essential to allow complex genome functions. Elucidation of chromatin composition and regulation is a critical issue in biology, because of the intimate connection of chromatin with all the essential information processes (transcription, replication, recombination, and repair). Chromatin proteins include architectural proteins and DNA topoisomerases, which regulate genome structure and remodelling at two hierarchical levels. This review is focussed on architectural proteins and topoisomerases from hyperthermophilic Archaea. In these organisms, which live at high environmental temperature (>80 °C <113 °C), chromatin proteins and modulation of the DNA secondary structure are concerned with the problem of DNA stabilization against heat denaturation while maintaining its metabolic activity. View Full-Text
Keywords: DNA topology; DNA structure; thermophilic organisms DNA topology; DNA structure; thermophilic organisms

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Visone, V.; Vettone, A.; Serpe, M.; Valenti, A.; Perugino, G.; Rossi, M.; Ciaramella, M. Chromatin Structure and Dynamics in Hot Environments: Architectural Proteins and DNA Topoisomerases of Thermophilic Archaea. Int. J. Mol. Sci. 2014, 15, 17162-17187.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top