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Int. J. Mol. Sci. 2014, 15(7), 11760-11772;

Paeonol Suppresses Chondrosarcoma Metastasis through Up-Regulation of miR-141 by Modulating PKCδ and c-Src Signaling Pathway

Medical Education Center, Kaohsiung Armed Force General Hospital, Kaohsiung 802, Taiwan
Department of Pharmacy, Tajen University, Pingtung 907, Taiwan
Graduate Institute of Basic Medical Science, China Medical University, Taichung 404, Taiwan
Department of Pharmacology, School of Medicine, China Medical University, Taichung 404, Taiwan
Department of Orthopedic Surgery, Taichung Hospital, Ministry of Health and Welfare, Taichung 403, Taiwan
School of Chinese Medicine, China Medical University, Taichung 404, Taiwan
Department of Nursing, National Taichung University of Science and Technology, Taichung 403, Taiwan
Graduate Institute of Biotechnology, National Chung Hsing University, Taichung 402, Taiwan
Department of Biotechnology, College of Health Science, Asia University, Taichung 413, Taiwan
Author to whom correspondence should be addressed.
Received: 16 April 2014 / Revised: 10 June 2014 / Accepted: 13 June 2014 / Published: 2 July 2014
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
Full-Text   |   PDF [1384 KB, uploaded 2 July 2014]   |  


Chondrosarcoma, a primary malignant bone cancer, has potential for local invasion and distant metastasis, especially to the lungs. Patients diagnosed with it show poor prognosis. Paeonol (2'-hydroxy-4'-methoxyacetophenone), the main active compound of traditional Chinese remedy Paeonia lactiflora Pallas, exhibits anti-inflammatory and anti-tumor activity; whether paeonol regulates metastatic chondrosarcoma is largely unknown. Here, we find paeonol do not increase apoptosis. By contrast, at non-cytotoxic concentrations, paeonol suppresses migration and invasion of chondrosarcoma cells. We also demonstrate paeonol enhancing miR-141 expression and miR-141 inhibitor reversing paeonol-inhibited cell motility; paeonol also reduces protein kinase C (PKC)d and c-Src kinase activity. Since paeonol inhibits migration and invasion of human chondrosarcoma via up-regulation of miR-141 via PKCd and c-Src pathways, it thus might be a novel anti-metastasis agent for treatment of metastatic chondrosarcoma. View Full-Text
Keywords: paeonol; chondrosarcoma; miR-141; metastasis paeonol; chondrosarcoma; miR-141; metastasis

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Horng, C.-T.; Shieh, P.-C.; Tan, T.-W.; Yang, W.-H.; Tang, C.-H. Paeonol Suppresses Chondrosarcoma Metastasis through Up-Regulation of miR-141 by Modulating PKCδ and c-Src Signaling Pathway. Int. J. Mol. Sci. 2014, 15, 11760-11772.

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