Next Article in Journal
Genes and Gene Networks Involved in Sodium Fluoride-Elicited Cell Death Accompanying Endoplasmic Reticulum Stress in Oral Epithelial Cells
Previous Article in Journal
Tagging SNPs in the MTHFR Gene and Risk of Ischemic Stroke in a Chinese Population
Article Menu

Export Article

Open AccessArticle
Int. J. Mol. Sci. 2014, 15(5), 8941-8958;

Synthesis and Bioactivity of 5-Substituted-2-furoyl Diacylhydazide Derivatives with Aliphatic Chain

Guangdong Province Key Laboratory of Microbial Signals and Disease Control, Department of Plant Pathology, College of Natural Resources and Environment, South China Agricultural University, Guangzhou 510642, China
State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China
Department of Pesticide Science, Plant Protection College, Shenyang Agricultural University, Shenyang 110866, China
Authors to whom correspondence should be addressed.
Received: 24 March 2014 / Revised: 2 May 2014 / Accepted: 5 May 2014 / Published: 20 May 2014
(This article belongs to the Section Materials Science)
Full-Text   |   PDF [384 KB, uploaded 19 June 2014]


A series of 5-substituted-2-furoyl diacylhydazide derivatives with aliphatic chain were designed and synthesized. Their structures were characterized by IR, 1H NMR, elemental analysis, and X-ray single crystal diffraction. The anti-tumor bioassay revealed that some title compounds exhibited promising activity against the selected cancer cell lines, especially against the human promyelocytic leukemic cells (HL-60). Their fungicidal tests indicated that most of the title compounds showed significant anti-fungal activity. The preliminary structure-activity relationship showed that the aliphatic chain length and differences in the R2 group had obvious effects on the anti-tumor and anti-fungal activities. The bioassay results demonstrated that the title compounds hold great promise as novel lead compounds for further drug discovery. View Full-Text
Keywords: diacylhydrazide; aliphatic chain; synthesis; bioactivity diacylhydrazide; aliphatic chain; synthesis; bioactivity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Cui, Z.; Li, X.; Tian, F.; Yan, X. Synthesis and Bioactivity of 5-Substituted-2-furoyl Diacylhydazide Derivatives with Aliphatic Chain. Int. J. Mol. Sci. 2014, 15, 8941-8958.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top