Biomarkers of Treatment Toxicity in Combined-Modality Cancer Therapies with Radiation and Systemic Drugs:  Study Design, Multiplex Methods, Molecular Networks

Ree, Anne Hansen; Meltzer, Sebastian; Flatmark, Kjersti; Dueland, Svein; Kalanxhi, Erta

doi:10.3390/ijms151222835

Submit to this Journal Review for this Journal Edit a Special Issue

Article Menu

...

Open AccessReview

Biomarkers of Treatment Toxicity in Combined-Modality Cancer Therapies with Radiation and Systemic Drugs: Study Design, Multiplex Methods, Molecular Networks

^1,2,*,

^1,2,

^2,3,

⁴ and

Department of Oncology, Akershus University Hospital, P.O. Box 1000, 1478 Lørenskog, Norway

Institute of Clinical Medicine, University of Oslo, P.O. Box 1171 Blindern, 0318 Oslo, Norway

Department of Tumor Biology and Department of Gastroenterological Surgery, Oslo University Hospital, P.O. Box 4956 Nydalen, 0424 Oslo, Norway

⁴

Department of Oncology, Oslo University Hospital, P.O. Box 4956 Nydalen, 0424 Oslo, Norway

Author to whom correspondence should be addressed.

Int. J. Mol. Sci. 2014, 15(12), 22835-22856; https://doi.org/10.3390/ijms151222835

Received: 6 August 2014 / Revised: 23 November 2014 / Accepted: 2 December 2014 / Published: 9 December 2014

(This article belongs to the Special Issue Computational Toxicology: Predicting Potential Toxicity of Drugs and Therapeutics)

View Full-Text Download PDF

Browse Figures

Citation Export

Abstract

Organ toxicity in cancer therapy is likely caused by an underlying disposition for given pathophysiological mechanisms in the individual patient. Mechanistic data on treatment toxicity at the patient level are scarce; hence, probabilistic and translational linkages among different layers of data information, all the way from cellular targets of the therapeutic exposure to tissues and ultimately the patient’s organ systems, are required. Throughout all of these layers, untoward treatment effects may be viewed as perturbations that propagate within a hierarchically structured network from one functional level to the next, at each level causing disturbances that reach a critical threshold, which ultimately are manifested as clinical adverse reactions. Advances in bioinformatics permit compilation of information across the various levels of data organization, presumably enabling integrated systems biology-based prediction of treatment safety. In view of the complexity of biological responses to cancer therapy, this communication reports on a “top-down” strategy, starting with the systematic assessment of adverse effects within a defined therapeutic context and proceeding to transcriptomic and proteomic analysis of relevant patient tissue samples and computational exploration of the resulting data, with the ultimate aim of utilizing information from functional connectivity networks in evaluation of patient safety in multimodal cancer therapy. View Full-Text

Keywords: cancer treatment; radiotherapy; chemotherapy; targeted therapy; treatment toxicity; clinical study; biomarkers; proteomics; transcriptomics; systems analysis

▼ Show Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

Share and Cite

MDPI and ACS Style

Ree, A.H.; Meltzer, S.; Flatmark, K.; Dueland, S.; Kalanxhi, E. Biomarkers of Treatment Toxicity in Combined-Modality Cancer Therapies with Radiation and Systemic Drugs: Study Design, Multiplex Methods, Molecular Networks. Int. J. Mol. Sci. 2014, 15, 22835-22856. https://doi.org/10.3390/ijms151222835

AMA Style

Ree AH, Meltzer S, Flatmark K, Dueland S, Kalanxhi E. Biomarkers of Treatment Toxicity in Combined-Modality Cancer Therapies with Radiation and Systemic Drugs: Study Design, Multiplex Methods, Molecular Networks. International Journal of Molecular Sciences. 2014; 15(12):22835-22856. https://doi.org/10.3390/ijms151222835

Chicago/Turabian Style

Ree, Anne H., Sebastian Meltzer, Kjersti Flatmark, Svein Dueland, and Erta Kalanxhi. 2014. "Biomarkers of Treatment Toxicity in Combined-Modality Cancer Therapies with Radiation and Systemic Drugs: Study Design, Multiplex Methods, Molecular Networks" International Journal of Molecular Sciences 15, no. 12: 22835-22856. https://doi.org/10.3390/ijms151222835

Find Other Styles

Article Metrics

Abstract views Pdf views Html views

Article Access Map by Country/Region

Only visits after 24 November 2015 are recorded.

Article Menu

Biomarkers of Treatment Toxicity in Combined-Modality Cancer Therapies with Radiation and Systemic Drugs: Study Design, Multiplex Methods, Molecular Networks

Abstract

Share and Cite

Article Metrics

Article Access Statistics

Article Access Map by Country/Region

Further Information

Guidelines

MDPI Initiatives

Follow MDPI