Next Article in Journal
Combining Molecular Docking and Molecular Dynamics to Predict the Binding Modes of Flavonoid Derivatives with the Neuraminidase of the 2009 H1N1 Influenza A Virus
Next Article in Special Issue
Na+, K+-ATPase Subunit Composition in a Human Chondrocyte Cell Line; Evidence for the Presence of α1, α3, β1, β2 and β3 Isoforms
Previous Article in Journal
The Ascorbate-glutathione-α-tocopherol Triad in Abiotic Stress Response
Previous Article in Special Issue
Expression of Transient Receptor Potential Vanilloid (TRPV) Channels in Different Passages of Articular Chondrocytes
Article Menu

Export Article

Open AccessReview
Int. J. Mol. Sci. 2012, 13(4), 4484-4495;

Biochemistry of Bacterial Multidrug Efflux Pumps

QC Laboratory, Post Harvest Technology Department, Central Institute of Fisheries Education (CIFE), Versova, Mumbai 400061 India
Biology Department, Eastern New Mexico University, Portales New Mexico, 88130, USA
Author to whom correspondence should be addressed.
Received: 24 February 2012 / Revised: 9 March 2012 / Accepted: 15 March 2012 / Published: 10 April 2012
(This article belongs to the Special Issue Membrane Transport)
Full-Text   |   PDF [213 KB, uploaded 19 June 2014]


Bacterial pathogens that are multi-drug resistant compromise the effectiveness of treatment when they are the causative agents of infectious disease. These multi-drug resistance mechanisms allow bacteria to survive in the presence of clinically useful antimicrobial agents, thus reducing the efficacy of chemotherapy towards infectious disease. Importantly, active multi-drug efflux is a major mechanism for bacterial pathogen drug resistance. Therefore, because of their overwhelming presence in bacterial pathogens, these active multi-drug efflux mechanisms remain a major area of intense study, so that ultimately measures may be discovered to inhibit these active multi-drug efflux pumps. View Full-Text
Keywords: efflux pump; antibiotic resistance; MFS; antiporter; Tet; Qac efflux pump; antibiotic resistance; MFS; antiporter; Tet; Qac
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Kumar, S.; Varela, M.F. Biochemistry of Bacterial Multidrug Efflux Pumps. Int. J. Mol. Sci. 2012, 13, 4484-4495.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top