Biochemistry of Bacterial Multidrug Efflux Pumps
by
Sanath Kumar 1 and Manuel F. Varela 2,*
Sanath Kumar 1 and Manuel F. Varela 2,*
1
QC Laboratory, Post Harvest Technology Department, Central Institute of Fisheries Education (CIFE), Versova, Mumbai 400061 India
2
Biology Department, Eastern New Mexico University, Portales New Mexico, 88130, USA
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2012, 13(4), 4484-4495; https://doi.org/10.3390/ijms13044484
Received: 24 February 2012 / Revised: 9 March 2012 / Accepted: 15 March 2012 / Published: 10 April 2012
(This article belongs to the Special Issue Membrane Transport)
Bacterial pathogens that are multi-drug resistant compromise the effectiveness of treatment when they are the causative agents of infectious disease. These multi-drug resistance mechanisms allow bacteria to survive in the presence of clinically useful antimicrobial agents, thus reducing the efficacy of chemotherapy towards infectious disease. Importantly, active multi-drug efflux is a major mechanism for bacterial pathogen drug resistance. Therefore, because of their overwhelming presence in bacterial pathogens, these active multi-drug efflux mechanisms remain a major area of intense study, so that ultimately measures may be discovered to inhibit these active multi-drug efflux pumps.
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Keywords:
efflux pump; antibiotic resistance; MFS; antiporter; Tet; Qac
This is an open access article distributed under the Creative Commons Attribution License
MDPI and ACS Style
Kumar, S.; Varela, M.F. Biochemistry of Bacterial Multidrug Efflux Pumps. Int. J. Mol. Sci. 2012, 13, 4484-4495.
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