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Biaryl Product Formation from Cross-coupling in Palladiumcatalyzed Borylation of a Boc Protected Aminobromoquinoline Compound

Department of Chemistry, Georgia State University, 33 Gilmer St. S.E., Atlanta, GA 30303 USA
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Molecules 2004, 9(3), 178-184; https://doi.org/10.3390/90300178
Received: 18 February 2004 / Accepted: 20 February 2004 / Published: 28 February 2004
(This article belongs to the Special Issue Biologically Relevant Heterocyclic Compounds)
The palladium catalyzed borylation of a Boc protected aminobromoquinoline compound with bis(pinacolato)diboron yielded a biaryl compound, resulting from cross coupling, as the major product, instead of the intended boronate, even though no strong base was used. Such results indicate that under certain conditions and with certain substrates, cross coupling can be a major problem during borylation, leading to unintended consequences. View Full-Text
Keywords: Palladium-catalyzed reaction; Borylation; Cross-coupling. Palladium-catalyzed reaction; Borylation; Cross-coupling.
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Fang, H.; Yan, J.; Wang, B. Biaryl Product Formation from Cross-coupling in Palladiumcatalyzed Borylation of a Boc Protected Aminobromoquinoline Compound. Molecules 2004, 9, 178-184.

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