Next Article in Journal
Acid Yellow 9 Azo Dye Gets the Blues: An Optical Spectroscopy and DFT Study of Unusual Photochemistry in Multilayer Films with PAH and Chitosan
Next Article in Special Issue
Synthesis of First Copper Metal Complex of C=C Extended Curcuminoid Analogue: Structure, β-Cyclodextrin Association, and Biological Properties
Previous Article in Journal
A Pectin Polysaccharide from Arnebia szechenyi Kanitz and Its Digestion Product: Physicochemical Properties and Immunostimulatory and Antioxidant Activities
Previous Article in Special Issue
Beer-Derived (Poly)phenol Metabolism in Individuals With and Without Metabolic Syndrome: A Comparative Dietary Intervention
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Molecules
Volume 30
Issue 19
10.3390/molecules30193849
molecules-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Anti-Helicobacter pylori Activity and Gastroprotective Effects of Diacetylcurcumin and Four Metal Derivatives

by
Almanelly Agabo-Martínez
1,
Erika Gomez-Chang
1,
Erick Hernández-Hipólito
1,
Elizabet Estrada-Muñiz
2,
Carolina Escobedo-Martínez
3,
Marco A. Obregón-Mendoza
4,
Raúl G. Enríquez
4,
Libia Vega
2 and
Irma Romero
1,*
1
Departamento de Bioquímica, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Ciudad Universitaria, Ciudad de México 04510, Mexico
2
Departamento de Toxicología, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Zacatenco, Ciudad de México 07360, Mexico
3
Departamento de Farmacia, División de Ciencias Naturales y Exactas, Universidad de Guanajuato, Campus Guanajuato, Guanajuato 36050, Mexico
4
Instituto de Química, Universidad Nacional Autónoma de México (UNAM), Ciudad Universitaria, Ciudad de México 04510, Mexico
*
Author to whom correspondence should be addressed.
Molecules 2025, 30(19), 3849; https://doi.org/10.3390/molecules30193849
Submission received: 20 August 2025 / Revised: 18 September 2025 / Accepted: 21 September 2025 / Published: 23 September 2025
(This article belongs to the Special Issue Advances in Phenolic Based Complexes)
Browse Figures
Versions Notes

Abstract

Helicobacter pylori is the main etiological factor of gastritis, peptic ulcers, and gastric cancer. This bacterium’s antibiotic resistance has led to a lower eradication rate; therefore, new drugs with anti-H. pylori activity are needed. Curcumin exhibits multiple biological activities, but it has low stability and poor bioavailability. To overcome these disadvantages, different metal complexes have been synthesized. The objective of this study was to determine the in vitro anti-H. pylori activity of diacetylcurcumin (DAC), DAC2-Cu, DAC2-Zn, DAC2-Mn, and DAC2-Mg by obtaining the minimum inhibitory concentration of bacterial growth, and to investigate some mechanisms by which they could affect the bacteria (urease and DNA gyrase activities). Moreover, their gastroprotective potential was assayed in an ethanol-induced gastric ulcer model in mice. The results showed that DAC2-Cu and DAC2-Zn have good anti-H. pylori activity, exhibit specific activity against this bacterium, inhibit the urease activity, and provide 70% gastroprotection at a dose of 200 mg/kg of body weight. In a subacute toxicity study in mice, DAC2-Cu and DAC2-Zn did not cause death or any deleterious symptoms, nor did they have a significant effect on serum and urine biochemical parameters compared to control mice. These compounds are promising candidates for use in H. pylori eradication schemes.
Keywords: Helicobacter pylori; diacetylcurcumin complexes; gastroprotection; MIC; urease; subacute toxicity Helicobacter pylori; diacetylcurcumin complexes; gastroprotection; MIC; urease; subacute toxicity
Graphical Abstract

Share and Cite

MDPI and ACS Style

Agabo-Martínez, A.; Gomez-Chang, E.; Hernández-Hipólito, E.; Estrada-Muñiz, E.; Escobedo-Martínez, C.; Obregón-Mendoza, M.A.; Enríquez, R.G.; Vega, L.; Romero, I. Anti-Helicobacter pylori Activity and Gastroprotective Effects of Diacetylcurcumin and Four Metal Derivatives. Molecules 2025, 30, 3849. https://doi.org/10.3390/molecules30193849

AMA Style

Agabo-Martínez A, Gomez-Chang E, Hernández-Hipólito E, Estrada-Muñiz E, Escobedo-Martínez C, Obregón-Mendoza MA, Enríquez RG, Vega L, Romero I. Anti-Helicobacter pylori Activity and Gastroprotective Effects of Diacetylcurcumin and Four Metal Derivatives. Molecules. 2025; 30(19):3849. https://doi.org/10.3390/molecules30193849

Chicago/Turabian Style

Agabo-Martínez, Almanelly, Erika Gomez-Chang, Erick Hernández-Hipólito, Elizabet Estrada-Muñiz, Carolina Escobedo-Martínez, Marco A. Obregón-Mendoza, Raúl G. Enríquez, Libia Vega, and Irma Romero. 2025. "Anti-Helicobacter pylori Activity and Gastroprotective Effects of Diacetylcurcumin and Four Metal Derivatives" Molecules 30, no. 19: 3849. https://doi.org/10.3390/molecules30193849

APA Style

Agabo-Martínez, A., Gomez-Chang, E., Hernández-Hipólito, E., Estrada-Muñiz, E., Escobedo-Martínez, C., Obregón-Mendoza, M. A., Enríquez, R. G., Vega, L., & Romero, I. (2025). Anti-Helicobacter pylori Activity and Gastroprotective Effects of Diacetylcurcumin and Four Metal Derivatives. Molecules, 30(19), 3849. https://doi.org/10.3390/molecules30193849

Article Metrics

Back to TopTop