Next Article in Journal
Controlled Formation of α- and β-Bi2O3 with Tunable Morphologies for Visible-Light-Driven Photocatalysis
Previous Article in Journal
Photodegradation of Turmeric Oleoresin Under Fluorescent Light and White LED: Impacts on the Chemical Stability, Bioactivity, and Photosensitizing Property of Curcuminoids
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Molecules
Volume 30
Issue 15
10.3390/molecules30153188
molecules-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Communication

Supramolecular Detoxification Approach of Endotoxin Through Host–Guest Complexation by a Giant Macrocycle

by
Junyi Chen
,
Xiang Yu
,
Shujie Lin
,
Zihan Fang
,
Shenghui Li
,
Liguo Xie
,
Zhibing Zheng
* and
Qingbin Meng
*
Academy of Military Medical Sciences, Beijing 100850, China
*
Authors to whom correspondence should be addressed.
Molecules 2025, 30(15), 3188; https://doi.org/10.3390/molecules30153188
Submission received: 11 July 2025 / Revised: 24 July 2025 / Accepted: 29 July 2025 / Published: 30 July 2025
Browse Figures
Versions Notes

Abstract

In Gram-negative bacteria, lipopolysaccharides (LPSs, also known as endotoxin) can induce extensive immune responses that will enable victims to produce severe septic shock syndrome. Because of the high mortality of sepsis in the face of standard treatment, advance detoxification schemes are urgently needed in clinics. Herein, we described a supramolecular detoxification approach via direct host–guest complexation by a giant macrocycle. Cationic pentaphen[3]arene (CPP3) bearing multiple quaternary ammonium groups was screened as a candidate antidote. CPP3 exhibited robust binding affinity toward LPS with an association constant of (4.79 ± 0.29) × 108 M−1. Co-dosing with an equivalent amount of CPP3 has been demonstrated to decrease LPS-induced cytotoxicity on a cellular level through inhibiting ROS generation and proinflammatory cytokine expression. In vivo experiments have further proved that post-treatment by CPP3 could significantly improve the survival rate of LPS-poisoned mice from 0 to 100% over a period of 3 days, and inflammatory abnormalities and tissue damage were also alleviated.
Keywords: endotoxin; macrocycle; host–guest complexation; supramolecular detoxification approach endotoxin; macrocycle; host–guest complexation; supramolecular detoxification approach

Share and Cite

MDPI and ACS Style

Chen, J.; Yu, X.; Lin, S.; Fang, Z.; Li, S.; Xie, L.; Zheng, Z.; Meng, Q. Supramolecular Detoxification Approach of Endotoxin Through Host–Guest Complexation by a Giant Macrocycle. Molecules 2025, 30, 3188. https://doi.org/10.3390/molecules30153188

AMA Style

Chen J, Yu X, Lin S, Fang Z, Li S, Xie L, Zheng Z, Meng Q. Supramolecular Detoxification Approach of Endotoxin Through Host–Guest Complexation by a Giant Macrocycle. Molecules. 2025; 30(15):3188. https://doi.org/10.3390/molecules30153188

Chicago/Turabian Style

Chen, Junyi, Xiang Yu, Shujie Lin, Zihan Fang, Shenghui Li, Liguo Xie, Zhibing Zheng, and Qingbin Meng. 2025. "Supramolecular Detoxification Approach of Endotoxin Through Host–Guest Complexation by a Giant Macrocycle" Molecules 30, no. 15: 3188. https://doi.org/10.3390/molecules30153188

APA Style

Chen, J., Yu, X., Lin, S., Fang, Z., Li, S., Xie, L., Zheng, Z., & Meng, Q. (2025). Supramolecular Detoxification Approach of Endotoxin Through Host–Guest Complexation by a Giant Macrocycle. Molecules, 30(15), 3188. https://doi.org/10.3390/molecules30153188

Article Metrics

Back to TopTop