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Article

Curcumin Inhibits Lysophosphatidic Acid Mediated MCP-1 Expression via Blocking ROCK Signalling

1
School of Pharmacy, Pharmacy Australia Centre of Excellence, The University of Queensland, Woolloongabba, QLD 4102, Australia
2
Department of Pharmacy, Xinhua College of Sun Yat-sen University, Tianhe District, Guangzhou 510520, China
3
Sunshine Coast Health Institute, University of the Sunshine Coast, Birtinya, QLD 4575, Australia
4
Department of Endocrinology, First Affiliated Hospital, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230037, China
*
Author to whom correspondence should be addressed.
Academic Editor: Lars Porskjær Christensen
Molecules 2021, 26(8), 2320; https://doi.org/10.3390/molecules26082320
Received: 22 March 2021 / Revised: 12 April 2021 / Accepted: 14 April 2021 / Published: 16 April 2021
(This article belongs to the Special Issue Natural Products for Cardiovascular Disease)
Curcumin is a natural compound that has been widely used as a food additive and medicine in Asian countries. Over several decades, diverse biological effects of curcumin have been elucidated, such as anti-inflammatory and anti-oxidative activities. Monocyte chemoattractant protein-1 (MCP-1) is a key inflammatory marker during the development of atherosclerosis, and curcumin blocks MCP-1 expression stimulated by various ligands. Hence, we studied the action of curcumin on lysophosphatidic acid (LPA) mediated MCP-1 expression and explored the specific underlying mechanisms. In human vascular smooth muscle cells, LPA induces Rho-associated protein kinase (ROCK) dependent transforming growth factor receptor (TGFBR1) transactivation, leading to glycosaminoglycan chain elongation. We found that LPA also signals via the TGFBR1 transactivation pathway to regulate MCP-1 expression. Curcumin blocks LPA mediated TGFBR1 transactivation and subsequent MCP-1 expression by blocking the ROCK signalling. In the vasculature, ROCK signalling regulates smooth muscle cell contraction, inflammatory cell recruitment, endothelial dysfunction and vascular remodelling. Therefore, curcumin as a ROCK signalling inhibitor has the potential to prevent atherogenesis via multiple ways. View Full-Text
Keywords: transforming growth factor receptor; Smad2; inflammation; monocyte chemoattractant protein-1; atherosclerosis; vascular smooth muscle cells transforming growth factor receptor; Smad2; inflammation; monocyte chemoattractant protein-1; atherosclerosis; vascular smooth muscle cells
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MDPI and ACS Style

Zhou, Y.; Little, P.J.; Xu, S.; Kamato, D. Curcumin Inhibits Lysophosphatidic Acid Mediated MCP-1 Expression via Blocking ROCK Signalling. Molecules 2021, 26, 2320. https://doi.org/10.3390/molecules26082320

AMA Style

Zhou Y, Little PJ, Xu S, Kamato D. Curcumin Inhibits Lysophosphatidic Acid Mediated MCP-1 Expression via Blocking ROCK Signalling. Molecules. 2021; 26(8):2320. https://doi.org/10.3390/molecules26082320

Chicago/Turabian Style

Zhou, Ying, Peter J. Little, Suowen Xu, and Danielle Kamato. 2021. "Curcumin Inhibits Lysophosphatidic Acid Mediated MCP-1 Expression via Blocking ROCK Signalling" Molecules 26, no. 8: 2320. https://doi.org/10.3390/molecules26082320

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