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Review

Development and Effects of Influenza Antiviral Drugs

Key Laboratory of Fujian-Taiwan Animal Pathogen Biology, College of Animal Sciences (College of Bee Science), Fujian Agriculture and Forestry University, Fuzhou 350002, China
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Author to whom correspondence should be addressed.
Academic Editors: Libor Grubhoffer and Masanori Baba
Molecules 2021, 26(4), 810; https://doi.org/10.3390/molecules26040810
Received: 29 December 2020 / Revised: 28 January 2021 / Accepted: 1 February 2021 / Published: 4 February 2021
Influenza virus is a highly contagious zoonotic respiratory disease that causes seasonal outbreaks each year and unpredictable pandemics occasionally with high morbidity and mortality rates, posing a great threat to public health worldwide. Besides the limited effect of vaccines, the problem is exacerbated by the lack of drugs with strong antiviral activity against all flu strains. Currently, there are two classes of antiviral drugs available that are chemosynthetic and approved against influenza A virus for prophylactic and therapeutic treatment, but the appearance of drug-resistant virus strains is a serious issue that strikes at the core of influenza control. There is therefore an urgent need to develop new antiviral drugs. Many reports have shown that the development of novel bioactive plant extracts and microbial extracts has significant advantages in influenza treatment. This paper comprehensively reviews the development and effects of chemosynthetic drugs, plant extracts, and microbial extracts with influenza antiviral activity, hoping to provide some references for novel antiviral drug design and promising alternative candidates for further anti-influenza drug development. View Full-Text
Keywords: influenza virus; chemosynthetic drugs; plant extracts; microbial metabolites; drug resistance influenza virus; chemosynthetic drugs; plant extracts; microbial metabolites; drug resistance
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MDPI and ACS Style

Yin, H.; Jiang, N.; Shi, W.; Chi, X.; Liu, S.; Chen, J.-L.; Wang, S. Development and Effects of Influenza Antiviral Drugs. Molecules 2021, 26, 810. https://doi.org/10.3390/molecules26040810

AMA Style

Yin H, Jiang N, Shi W, Chi X, Liu S, Chen J-L, Wang S. Development and Effects of Influenza Antiviral Drugs. Molecules. 2021; 26(4):810. https://doi.org/10.3390/molecules26040810

Chicago/Turabian Style

Yin, Hang, Ning Jiang, Wenhao Shi, Xiaojuan Chi, Sairu Liu, Ji-Long Chen, and Song Wang. 2021. "Development and Effects of Influenza Antiviral Drugs" Molecules 26, no. 4: 810. https://doi.org/10.3390/molecules26040810

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