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Open AccessReview

Crystalline Peroxosolvates: Nature of the Coformer, Hydrogen-Bonded Networks and Clusters, Intermolecular Interactions

1
Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Leninskii Prosp. 31, 119991 Moscow, Russia
2
The Casali Center of Applied Chemistry, The Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
3
Department of Quantum Chemistry, Mendeleev University of Chemical Technology, Miusskaya Square 9, 125047 Moscow, Russia
*
Authors to whom correspondence should be addressed.
Academic Editors: Patrizia Ferraboschi and Fiorella Meneghetti
Molecules 2021, 26(1), 26; https://doi.org/10.3390/molecules26010026
Received: 4 December 2020 / Revised: 19 December 2020 / Accepted: 19 December 2020 / Published: 23 December 2020
Despite the technological importance of urea perhydrate (percarbamide) and sodium percarbonate, and the growing technological attention to solid forms of peroxide, fewer than 45 peroxosolvates were known by 2000. However, recent advances in X-ray diffractometers more than tripled the number of structurally characterized peroxosolvates over the last 20 years, and even more so, allowed energetic interpretation and gleaning deeper insight into peroxosolvate stability. To date, 134 crystalline peroxosolvates have been structurally resolved providing sufficient insight to justify a first review article on the subject. In the first chapter of the review, a comprehensive analysis of the structural databases is carried out revealing the nature of the co-former in crystalline peroxosolvates. In the majority of cases, the coformers can be classified into three groups: (1) salts of inorganic and carboxylic acids; (2) amino acids, peptides, and related zwitterions; and (3) molecular compounds with a lone electron pair on nitrogen and/or oxygen atoms. The second chapter of the review is devoted to H-bonding in peroxosolvates. The database search and energy statistics revealed the importance of intermolecular hydrogen bonds (H-bonds) which play a structure-directing role in the considered crystals. H2O2 always forms two H-bonds as a proton donor, the energy of which is higher than the energy of analogous H-bonds existing in isostructural crystalline hydrates. This phenomenon is due to the higher acidity of H2O2 compared to water and the conformational mobility of H2O2. The dihedral angle H-O-O-H varies from 20 to 180° in crystalline peroxosolvates. As a result, infinite H-bonded 1D chain clusters are formed, consisting of H2O2 molecules, H2O2 and water molecules, and H2O2 and halogen anions. H2O2 can form up to four H-bonds as a proton acceptor. The third chapter of the review is devoted to energetic computations and in particular density functional theory with periodic boundary conditions. The approaches are considered in detail, allowing one to obtain the H-bond energies in crystals. DFT computations provide deeper insight into the stability of peroxosolvates and explain why percarbamide and sodium percarbonate are stable to H2O2/H2O isomorphic transformations. The review ends with a description of the main modern trends in the synthesis of crystalline peroxosolvates, in particular, the production of peroxosolvates of high-energy compounds and mixed pharmaceutical forms with antiseptic and analgesic effects. View Full-Text
Keywords: two-component crystals; isomorphous H2O2/H2O substitution; periodic DFT computations; hydrogen bond enthalpy and energy; peroxosolvates of high-energy compounds; mixed pharmaceutical forms; hydrogen peroxide two-component crystals; isomorphous H2O2/H2O substitution; periodic DFT computations; hydrogen bond enthalpy and energy; peroxosolvates of high-energy compounds; mixed pharmaceutical forms; hydrogen peroxide
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MDPI and ACS Style

Medvedev, A.G.; Churakov, A.V.; Prikhodchenko, P.V.; Lev, O.; Vener, M.V. Crystalline Peroxosolvates: Nature of the Coformer, Hydrogen-Bonded Networks and Clusters, Intermolecular Interactions. Molecules 2021, 26, 26. https://doi.org/10.3390/molecules26010026

AMA Style

Medvedev AG, Churakov AV, Prikhodchenko PV, Lev O, Vener MV. Crystalline Peroxosolvates: Nature of the Coformer, Hydrogen-Bonded Networks and Clusters, Intermolecular Interactions. Molecules. 2021; 26(1):26. https://doi.org/10.3390/molecules26010026

Chicago/Turabian Style

Medvedev, Alexander G.; Churakov, Andrei V.; Prikhodchenko, Petr V.; Lev, Ovadia; Vener, Mikhail V. 2021. "Crystalline Peroxosolvates: Nature of the Coformer, Hydrogen-Bonded Networks and Clusters, Intermolecular Interactions" Molecules 26, no. 1: 26. https://doi.org/10.3390/molecules26010026

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