Next Article in Journal
Structure-Based Design, Synthesis and Bioactivity of a New Anti-TNFα Cyclopeptide
Previous Article in Journal
Impact of Fermentation on the Phenolic Compounds and Antioxidant Activity of Whole Cereal Grains: A Mini Review
Open AccessArticle

Bacterial Cellulose-Alginate Composite Beads as Yarrowia lipolytica Cell Carriers for Lactone Production

Department of Biological Engineering, Shanghai Institute of Technology, No. 100 Haiquan Road, Fengxian District, Shanghai 201418, China
*
Authors to whom correspondence should be addressed.
Molecules 2020, 25(4), 928; https://doi.org/10.3390/molecules25040928
Received: 6 January 2020 / Revised: 9 February 2020 / Accepted: 13 February 2020 / Published: 19 February 2020
The demand for natural lactone gamma-decalactone (GDL) has increased in the fields of food and cosmetic products. However, low productivity during bioprocessing limits its industrial production. In this study, a novel composite porous cell carrier, bacterial cellulose-alginate (BC-ALG), was used for long-term biotransformation and production of GDL. The effects of this carrier on biotransformation and related mechanisms were investigated. BC-ALG carriers showed improved mechanical strength over ALG carriers, with their internal embedded cell pattern changed to an interconnected porous structure. In five repeated-batch biotransformation experiments, the maximum concentration of GDL obtained in culture with BC-ALG carriers was 8.37 g/L, approximately 3.7 times higher than that from the medium with an ALG carrier alone. The result indicated that multiple hydrogen bonding interactions at the interface between BC and ALG contributed to the compatibility and stability of BC-ALG carriers. On the basis of the above results, the BC-ALG composite carrier can be considered ideal for immobilisation of cells for the production of GDL on an industrial scale, and has the potential to be utilised in other biological processes. View Full-Text
Keywords: gamma-decalactone; immobilisation; alginate; bacterial cellulose; Yarrowia lipolytica gamma-decalactone; immobilisation; alginate; bacterial cellulose; Yarrowia lipolytica
Show Figures

Figure 1

MDPI and ACS Style

Zhang, S.; He, H.; Guan, S.; Cai, B.; Li, Q.; Rong, S. Bacterial Cellulose-Alginate Composite Beads as Yarrowia lipolytica Cell Carriers for Lactone Production. Molecules 2020, 25, 928.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop