Next Article in Journal
Analysis of the Effect of the Biomass Torrefaction Process on Selected Parameters of Dust Explosivity
Next Article in Special Issue
Cyanidin-3-O-Glucoside-Rich Haskap Berry Administration Suppresses Carcinogen-Induced Lung Tumorigenesis in A/JCr Mice
Previous Article in Journal
Synergistic Effect of a Pleuromutilin Derivative with Tetracycline against Streptococcus suis In Vitro and in the Neutropenic Thigh Infection Model
Previous Article in Special Issue
Flavonoid and Non-Flavonoid Compounds of Autumn Royal and Egnatia Grape Skin Extracts Affect Membrane PUFA’s Profile and Cell Morphology in Human Colon Cancer Cell Lines
Review

Cranberry Polyphenols and Prevention against Urinary Tract Infections: Relevant Considerations

Institute of Food Science Research (CIAL), CSIC-UAM, Nicolás Cabrera, 9, Campus de Cantoblanco, 28049 Madrid, Spain
*
Author to whom correspondence should be addressed.
Academic Editor: H.P. Vasantha Rupasinghe
Molecules 2020, 25(15), 3523; https://doi.org/10.3390/molecules25153523
Received: 16 July 2020 / Revised: 28 July 2020 / Accepted: 29 July 2020 / Published: 1 August 2020
(This article belongs to the Special Issue Flavonoids and Their Disease Prevention and Treatment Potential)
Cranberry (Vaccinium macrocarpon) is a distinctive source of polyphenols as flavonoids and phenolic acids that has been described to display beneficial effects against urinary tract infections (UTIs), the second most common type of infections worldwide. UTIs can lead to significant morbidity, especially in healthy females due to high rates of recurrence and antibiotic resistance. Strategies and therapeutic alternatives to antibiotics for prophylaxis and treatment against UTIs are continuously being sought after. Different to cranberry, which have been widely recommended in traditional medicine for UTIs prophylaxis, probiotics have emerged as a new alternative to the use of antibiotics against these infections and are the subject of new research in this area. Besides uropathogenic Escherichia coli (UPEC), the most common bacteria causing uncomplicated UTIs, other etiological agents, such as Klebsiellapneumoniae or Gram-positive bacteria of Enterococcus and Staphylococcus genera, seem to be more widespread than previously appreciated. Considerable current effort is also devoted to the still-unraveled mechanisms that are behind the UTI-protective effects of cranberry, probiotics and their new combined formulations. All these current topics in the understanding of the protective effects of cranberry against UTIs are reviewed in this paper. Further progresses expected in the coming years in these fields are also discussed. View Full-Text
Keywords: cranberry; urinary tract infections; UTIs; uropathogenic Escherichia coli; UPEC; flavan-3-ols; A-type proanthocyanidins; phenolic metabolites; antiadhesive activity; probiotics cranberry; urinary tract infections; UTIs; uropathogenic Escherichia coli; UPEC; flavan-3-ols; A-type proanthocyanidins; phenolic metabolites; antiadhesive activity; probiotics
Show Figures

Figure 1

MDPI and ACS Style

González de Llano, D.; Moreno-Arribas, M.V.; Bartolomé, B. Cranberry Polyphenols and Prevention against Urinary Tract Infections: Relevant Considerations. Molecules 2020, 25, 3523. https://doi.org/10.3390/molecules25153523

AMA Style

González de Llano D, Moreno-Arribas MV, Bartolomé B. Cranberry Polyphenols and Prevention against Urinary Tract Infections: Relevant Considerations. Molecules. 2020; 25(15):3523. https://doi.org/10.3390/molecules25153523

Chicago/Turabian Style

González de Llano, Dolores, M. V. Moreno-Arribas, and Begoña Bartolomé. 2020. "Cranberry Polyphenols and Prevention against Urinary Tract Infections: Relevant Considerations" Molecules 25, no. 15: 3523. https://doi.org/10.3390/molecules25153523

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop