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Article

Synthesis and Antimicrobial Studies of Coumarin-Substituted Pyrazole Derivatives as Potent Anti-Staphylococcus aureus Agents

1
Department of Chemistry and Physics, College of Science and Mathematics, Arkansas State University, Jonesboro, AR 72467, USA
2
Department of Biological Sciences, College of Science and Mathematics, Arkansas State University, Jonesboro, AR 72467, USA
*
Author to whom correspondence should be addressed.
Molecules 2020, 25(12), 2758; https://doi.org/10.3390/molecules25122758
Received: 21 May 2020 / Revised: 9 June 2020 / Accepted: 12 June 2020 / Published: 15 June 2020
In this paper, synthesis and antimicrobial studies of 31 novel coumarin-substituted pyrazole derivatives are reported. Some of these compounds have shown potent activity against methicillin-resistant Staphylococcus aureus (MRSA) with minimum inhibitory concentration (MIC) as low as 3.125 µg/mL. These molecules are equally potent at inhibiting the development of MRSA biofilm and the destruction of preformed biofilm. These results are very significant as MRSA strains have emerged as one of the most menacing pathogens of humans and this bacterium is bypassing HIV in terms of fatality rate. View Full-Text
Keywords: pyrazole; coumarin; antimicrobial; hydrazone; biofilm; Staphylococcus aureus; S. epidermidis; MRSA pyrazole; coumarin; antimicrobial; hydrazone; biofilm; Staphylococcus aureus; S. epidermidis; MRSA
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MDPI and ACS Style

Alnufaie, R.; Raj KC, H.; Alsup, N.; Whitt, J.; Andrew Chambers, S.; Gilmore, D.; Alam, M.A. Synthesis and Antimicrobial Studies of Coumarin-Substituted Pyrazole Derivatives as Potent Anti-Staphylococcus aureus Agents. Molecules 2020, 25, 2758. https://doi.org/10.3390/molecules25122758

AMA Style

Alnufaie R, Raj KC H, Alsup N, Whitt J, Andrew Chambers S, Gilmore D, Alam MA. Synthesis and Antimicrobial Studies of Coumarin-Substituted Pyrazole Derivatives as Potent Anti-Staphylococcus aureus Agents. Molecules. 2020; 25(12):2758. https://doi.org/10.3390/molecules25122758

Chicago/Turabian Style

Alnufaie, Rawan, Hansa Raj KC, Nickolas Alsup, Jedidiah Whitt, Steven Andrew Chambers, David Gilmore, and Mohammad A. Alam 2020. "Synthesis and Antimicrobial Studies of Coumarin-Substituted Pyrazole Derivatives as Potent Anti-Staphylococcus aureus Agents" Molecules 25, no. 12: 2758. https://doi.org/10.3390/molecules25122758

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