Next Article in Journal
Cytokine Expression by Human Macrophage-Like Cells Derived from the Monocytic Cell Line THP-1 Differs between Treatment with Milk from Preterm- and Term-Delivering Mothers and Pasteurized Donor Milk
Previous Article in Journal
Bioactivity of Isostructural Hydrogen Bonding Frameworks Built from Pipemidic Acid Metal Complexes
Previous Article in Special Issue
A Unique Gene-Silencing Approach, Using an Intelligent RNA Expression Device (iRed), Results in Minimal Immune Stimulation When Given by Local Intrapleural Injection in Malignant Pleural Mesothelioma
Open AccessArticle

Two Sides to the Same Coin—Cytotoxicity vs. Potential Metastatic Activity of AgNPs Relative to Triple-Negative Human Breast Cancer MDA-MB-436 Cells

1
Department of Molecular Biology and Translational Research, Institute of Rural Health, 20-090 Lublin, Poland
2
Department of Histology and Embryology with Experimental Cytology Unit, Medical University of Lublin, 20-059 Lublin, Poland
3
The President Stanisław Wojciechowski State University of Applied Sciences, 62-800 Kalisz, Poland
4
Center for Radiobiology and Biological Dosimetry, Institute of Nuclear Chemistry and Technology, 03-195 Warsaw, Poland
*
Author to whom correspondence should be addressed.
Academic Editor: Fabio Pastorino
Molecules 2020, 25(10), 2375; https://doi.org/10.3390/molecules25102375
Received: 26 March 2020 / Revised: 7 May 2020 / Accepted: 18 May 2020 / Published: 20 May 2020
(This article belongs to the Special Issue Recent Advances in Precision Nanomedicine for Cancer)
Silver nanoparticles (AgNPs) are used in many fields of industry and medicine. Despite the well-established antimicrobial activity, AgNPs are foreseen to be used as anticancer drugs due to the unusual feature—inability to induce drug resistance in cancer cells. The aim of the study was to assess biological activity of AgNPs against MDA-MB-436 cells. The cells were derived from triple-negative breast cancer, a type of breast cancer with poor prognosis and is particularly difficult to cure. AgNPs were toxic to MDA-MB-436 cells and the probable mechanism of toxicity was the induction of oxidative stress. These promising effects, giving the opportunity to use AgNPs as an anti-cancer agent should, however, be treated with caution in the light of further results. Namely, the treatment of MDA-MB-436 cells with AgNPs was associated with the increased secretion of several cytokines and chemokines, which were important in breast cancer metastasis. Finally, changes in the actin cytoskeleton of MDA-MB-436 cells under the influence of AgNPs treatment were also observed. View Full-Text
Keywords: MDA-MB-436; breast cancer; silver nanoparticles; cytotoxicity; oxidative stress; inflammation; actin cytoskeleton; metastasis MDA-MB-436; breast cancer; silver nanoparticles; cytotoxicity; oxidative stress; inflammation; actin cytoskeleton; metastasis
Show Figures

Figure 1

MDPI and ACS Style

Matysiak-Kucharek, M.; Czajka, M.; Jodłowska-Jędrych, B.; Sawicki, K.; Wojtyła-Buciora, P.; Kruszewski, M.; Kapka-Skrzypczak, L. Two Sides to the Same Coin—Cytotoxicity vs. Potential Metastatic Activity of AgNPs Relative to Triple-Negative Human Breast Cancer MDA-MB-436 Cells. Molecules 2020, 25, 2375.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop