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Molecules 2019, 24(6), 1028;

Microbial Transformation of Flavonoids by Isaria fumosorosea ACCC 37814

The National Key Facility for Crop Gene Resources and Genetic Improvement, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, 12 Zhongguancun South Street, Beijing 100081, China
Author to whom correspondence should be addressed.
Received: 11 February 2019 / Revised: 6 March 2019 / Accepted: 11 March 2019 / Published: 15 March 2019
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Glycosylation is an efficient strategy to modulate the solubility, stability, bioavailability and bioactivity of drug-like natural products. Biological methods, such as whole-cell biocatalyst, promise a simple but highly effective approach to glycosylate biologically active small molecules with remarkable regio- and stereo-selectivity. Herein, we use the entomopathogenic filamentous fungus Isaria fumosorosea ACCC 37814 to biotransform a panel of phenolic natural products, including flavonoids and anthraquinone, into their glycosides. Six new flavonoid (4-O-methyl)glucopyranosides are obtained and structurally characterized using high resolution mass and nuclear magnetic resonance spectroscopic techniques. These compounds further expand the structural diversity of flavonoid glycosides and may be used in biological study. View Full-Text
Keywords: Isaria fumosorosea; flavonoids; microbial transformation; methylglycosylation Isaria fumosorosea; flavonoids; microbial transformation; methylglycosylation

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Dou, F.; Wang, Z.; Li, G.; Dun, B. Microbial Transformation of Flavonoids by Isaria fumosorosea ACCC 37814. Molecules 2019, 24, 1028.

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