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Molecules 2019, 24(4), 678;

Bioactivity Profile of the Diterpene Isosteviol and its Derivatives

Department of Chemistry, Islamia College University Peshawar, Peshawar 25120, Pakistan
Department of Pharmacy, King Khalid University, Abha 62529, Saudi Arabia
Authors to whom correspondence should be addressed.
Academic Editor: Isabel C.F.R. Ferreira
Received: 13 January 2019 / Revised: 3 February 2019 / Accepted: 6 February 2019 / Published: 14 February 2019
(This article belongs to the Collection Bioactive Compounds)
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Steviosides, rebaudiosides and their analogues constitute a major class of naturally occurring biologically active diterpene compounds. The wide spectrum of pharmacological activity of this group of compounds has developed an interest among medicinal chemists to synthesize, purify, and analyze more selective and potent isosteviol derivatives. It has potential biological applications and improves the field of medicinal chemistry by designing novel drugs with the ability to cope against resistance developing diseases. The outstanding advancement in the design and synthesis of isosteviol and its derivative has proved its effectiveness and importance in the field of medicinal chemical research. The present review is an effort to integrate recently developed novel drugs syntheses from isosteviol and potentially active pharmacological importance of the isosteviol derivatives covering the recent advances. View Full-Text
Keywords: stevioside; isosteviol; antitumor; diterpenoids; natural products stevioside; isosteviol; antitumor; diterpenoids; natural products

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Ullah, A.; Munir, S.; Mabkhot, Y.; Badshah, S.L. Bioactivity Profile of the Diterpene Isosteviol and its Derivatives. Molecules 2019, 24, 678.

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