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Open AccessArticle

Antiradical and Antioxidative Activity of Azocalix[4]arene Derivatives: Combined Experimental and Theoretical Study

by 1,2, 1,2,* and 2,3
1
State Key Laboratory of Refractories and Metallurgy, Wuhan University of Science and Technology, Wuhan 430081, China
2
Hubei Province Key Laboratory of Coal Conversion and New Carbon Materials, School of Chemistry and Chemical Engineering, Wuhan University of Science and Technology, Wuhan 430081, China
3
State Key Laboratory of Virology & Key Laboratory of Analytical Chemistry for Biology and Medicine, College of Chemistry and Molecular Science, Wuhan University, Wuhan 430072, China
*
Author to whom correspondence should be addressed.
Molecules 2019, 24(3), 485; https://doi.org/10.3390/molecules24030485
Received: 15 January 2019 / Revised: 27 January 2019 / Accepted: 28 January 2019 / Published: 29 January 2019
Developing antioxidants with high efficiency is fundamentally important for the protection of living cells and engineering materials against oxidative damage. In this present study, two azocalix[4]arene derivatives were synthesized via a diazo coupling reaction between calix[4]arene and diazonium salts. Their antiradical and antioxidative performances were evaluated by hydroxyl radical scavenging and pyrogallol autoxidation inhibition experiments. Combined with theoretical studies, the antiradical and antioxidative mechanisms have been explored. The results demonstrated that these two azocalix[4]arene derivatives both exhibited remarkable antiradical and antioxidative activity. The macrocyclic framework of the calix[4]arene and para-azo substituent group at the upper rim of calix[4]arene contributed synergistically and importantly to its excellent antiradical and antioxidant activity. View Full-Text
Keywords: azocalix[4]arene; antiradical; antioxidant; mechanism; density functional theory azocalix[4]arene; antiradical; antioxidant; mechanism; density functional theory
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MDPI and ACS Style

Ni, J.; Lu, L.; Liu, Y. Antiradical and Antioxidative Activity of Azocalix[4]arene Derivatives: Combined Experimental and Theoretical Study. Molecules 2019, 24, 485. https://doi.org/10.3390/molecules24030485

AMA Style

Ni J, Lu L, Liu Y. Antiradical and Antioxidative Activity of Azocalix[4]arene Derivatives: Combined Experimental and Theoretical Study. Molecules. 2019; 24(3):485. https://doi.org/10.3390/molecules24030485

Chicago/Turabian Style

Ni, Jiaqi; Lu, Lilin; Liu, Yi. 2019. "Antiradical and Antioxidative Activity of Azocalix[4]arene Derivatives: Combined Experimental and Theoretical Study" Molecules 24, no. 3: 485. https://doi.org/10.3390/molecules24030485

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