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Open AccessArticle

Design, Synthesis, and Bioactivity Evaluation of Novel Isoxazole-Amide Derivatives Containing an Acylhydrazone Moiety as New Active Antiviral Agents

by Zai-Bo Yang 1,*,†, Pei Li 1,2,*,† and Yin-Ju He 1
1
School of Chemistry and Chemical Engineering, Qiannan Normal University for Nationalities, Duyun 558000, China
2
Qiandongnan Engineering and Technology Research Center for Comprehensive Utilization of National Medicine, Kaili University, Kaili 556011, China
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Antonio Carta
Molecules 2019, 24(20), 3766; https://doi.org/10.3390/molecules24203766
Received: 2 September 2019 / Revised: 16 October 2019 / Accepted: 18 October 2019 / Published: 19 October 2019
(This article belongs to the Special Issue Antiviral Agents)
As a continuation of our efforts to discover and develop “me-better” active molecules, in this study, a series of novel isoxazole-amide derivatives containing an acylhydrazone moiety were synthesized and evaluated for their antiviral activities against tobacco mosaic virus (TMV) and cucumber mosaic virus (CMV). Antiviral bioassays indicated that some of the target compounds exhibited better in vivo antiviral activities against TMV and CMV than those of Ningnanmycin (NNM). Especially, the compound 7t exhibited the best curative, protection, and inactivation activities against TMV and CMV which were superior to those of NNM. Meanwhile, our present work also revealed that compound 7t could enhance the defense-related enzyme activity and increase the chlorophyll content in tobacco leaves to induce resistance and enhance plant tolerance to TMV infection. View Full-Text
Keywords: isoxazole-amide; acylhydrazone; synthesis; antiviral activity isoxazole-amide; acylhydrazone; synthesis; antiviral activity
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MDPI and ACS Style

Yang, Z.-B.; Li, P.; He, Y.-J. Design, Synthesis, and Bioactivity Evaluation of Novel Isoxazole-Amide Derivatives Containing an Acylhydrazone Moiety as New Active Antiviral Agents. Molecules 2019, 24, 3766.

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