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Article

Essential Oil Composition of Alluaudia procera and in Vitro Biological Activity on Two Drug-Resistant Models

1
Department of Biological, Chemical and Pharmaceutical Science and Technology (STEBICEF), University of Palermo, Viale delle Scienze, 90128 Palermo, Italy
2
Department of Agricultural, Food and Forest Sciences, University of Palermo Viale delle Scienze, 90128 Palermo, Italy
3
Department of Plant Biology and Ecology, University of Antananarivo, PO Box 906, Antananarivo 101, Madagascar
*
Authors to whom correspondence should be addressed.
Molecules 2019, 24(16), 2871; https://doi.org/10.3390/molecules24162871
Received: 24 June 2019 / Revised: 3 August 2019 / Accepted: 5 August 2019 / Published: 7 August 2019
Drug resistance is a major obstacle in antibiotic and antitumor chemotherapy. In response to the necessity to find new therapeutic strategies, plant secondary metabolites including essential oils (EOs) may represent one of the best sources. EOs in plants act as constitutive defenses against biotic and abiotic stress, and they play an important role in the pharmacology for their low toxicity, good pharmacokinetic and multitarget activity. In this context, natural products such as EOs are one of the most important sources of drugs used in pharmaceutical therapeutics. The aim of this paper was to identify the chemical composition of the essential oil of Alluaudia procera leaves, obtained by hydrodistillation and analysed by gas chromatography-mass spectrometry, and to verify its biological activities on acute myeloid leukemia cancer cell HL60 and its multidrugresistant variant HL60R and the Gram-positive Staphylococcus aureus exhibiting multi-antibiotic resistance. We speculate that cytotoxic and antibiotic effects observed in the tested resistant models may be due to the coordinate activities of forty compounds detected or to the C16 macrocyclic lactones which are the major ones (30%). Our data confirm the possibility of using EOs as therapeutic strategies in resistant models is due to the heterogeneous composition of the oils themselves. View Full-Text
Keywords: Didiereaceae; essential oil; acute myeloid leukemia cell; succulent plants Didiereaceae; essential oil; acute myeloid leukemia cell; succulent plants
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MDPI and ACS Style

Poma, P.; Labbozzetta, M.; Zito, P.; Alduina, R.; Ramarosandratana, A.V.; Bruno, M.; Rosselli, S.; Sajeva, M.; Notarbartolo, M. Essential Oil Composition of Alluaudia procera and in Vitro Biological Activity on Two Drug-Resistant Models. Molecules 2019, 24, 2871. https://doi.org/10.3390/molecules24162871

AMA Style

Poma P, Labbozzetta M, Zito P, Alduina R, Ramarosandratana AV, Bruno M, Rosselli S, Sajeva M, Notarbartolo M. Essential Oil Composition of Alluaudia procera and in Vitro Biological Activity on Two Drug-Resistant Models. Molecules. 2019; 24(16):2871. https://doi.org/10.3390/molecules24162871

Chicago/Turabian Style

Poma, Paola, Manuela Labbozzetta, Pietro Zito, Rosa Alduina, Aro V. Ramarosandratana, Maurizio Bruno, Sergio Rosselli, Maurizio Sajeva, and Monica Notarbartolo. 2019. "Essential Oil Composition of Alluaudia procera and in Vitro Biological Activity on Two Drug-Resistant Models" Molecules 24, no. 16: 2871. https://doi.org/10.3390/molecules24162871

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