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Open AccessReview

Carbazole Derivatives as Antiviral Agents: An Overview

1
Department of Pharmacy, Health & Nutritional Sciences, University of Calabria, 87036 Arcavacata di Rende, Italy
2
Department of Science, University of Basilicata, 85100 Potenza, Italy
3
UOC Microbiologia e Virologia AO Annunziata, 87100 Cosenza, Italy
*
Authors to whom correspondence should be addressed.
Co-senior authors, these authors contributed equally to the present work.
Molecules 2019, 24(10), 1912; https://doi.org/10.3390/molecules24101912
Received: 10 April 2019 / Revised: 6 May 2019 / Accepted: 15 May 2019 / Published: 17 May 2019
(This article belongs to the Special Issue Recent Advances in the Development of Antiviral Agents)
Viruses represent the most common cause of infectious diseases worldwide and those with rapid propagation and high infection rates cause human and animal pandemics. These fast-spreading diseases are generally treated with antiviral drugs but, often, drug resistance occurs because of the ability of the pathogens to mutate rapidly and become less susceptible to the treatments. Even though new antivirals have been approved, e.g., in HIV (human immunodeficiency virus) and HCV (hepatitis C virus) therapeutic areas, the need to dispose of new pharmaceutical tools for the management of infections that still have no treatment is of growing interest. In these areas, carbazole represents an important privileged scaffold in drug discovery. Many compounds with a carbazolic core have been developed and some of them have shown antiviral activity. This review provides an overview on some already known carbazole derivatives, pointing the attention on the running progresses in identifying new molecules with carbazolic structure, that have shown interesting and encouraging in vitro and in vivo properties. These drugs may be exploited as valid alternatives in antiviral therapy. View Full-Text
Keywords: carbazole; tetrahydrocarbazole; antiviral agents carbazole; tetrahydrocarbazole; antiviral agents
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MDPI and ACS Style

Caruso, A.; Ceramella, J.; Iacopetta, D.; Saturnino, C.; Mauro, M.V.; Bruno, R.; Aquaro, S.; Sinicropi, M.S. Carbazole Derivatives as Antiviral Agents: An Overview. Molecules 2019, 24, 1912.

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