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Open AccessArticle

Cytotoxic Effects of Compounds Isolated from Ricinodendron heudelotii

1
Department of Biochemistry, College of Science and Technology, Covenant University, Canaan Land, Ota PMB 1023, Ogun State, Nigeria
2
State Key Laboratory of Phytochemistry and Plant Resources of West China, Kunming Institute of Botany, Chinese Academy of Sciences. #132, Lanhei Road, Heilongtan, Kunming 650201, China
*
Authors to whom correspondence should be addressed.
Molecules 2019, 24(1), 145; https://doi.org/10.3390/molecules24010145
Received: 10 August 2018 / Revised: 31 October 2018 / Accepted: 22 November 2018 / Published: 2 January 2019
(This article belongs to the Special Issue Natural Product Isolation, Identification and Biological Activity)
This study was designed to explore the in vitro anticancer effects of the bioactive compounds isolated from Ricinodendron heudelotii on selected cancer cell lines. The leaves of the plant were extracted with ethanol and partitioned in sequence with petroleum ether, ethyl acetate, and n-butanol. The ethyl acetate fraction was phytochemically studied using thin layer chromatography (TLC) and column chromatography (CC). Structural elucidation of pure compounds obtained from the ethyl acetate fraction was done using mass spectra, 1H-NMR, and 13C-NMR analysis. The isolated compounds were subsequently screened using five different cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7, SW-480, and normal lung epithelial cell line, BEAS-2B, to assess their cytotoxic effects. Nine compounds were isolated and structurally elucidated as gallic acid, gallic acid ethyl ester, corilagin, quercetin-3-O-rhamnoside, myricetin-3-O-rhamnoside, 1,4,6-tri-O-galloyl glucose, 3,4,6-tri-O-galloyl glucose, 1,2,6-tri-O-galloyl glucose, and 4,6-di-O-galloyl glucose. Corilagin exhibited the most cytotoxic activity with an IC50 value of 33.18 μg/mL against MCF-7 cells, which were comparable to cisplatin with an IC50 value of 27.43 µg/mL. The result suggests that corilagin isolated from R. heudelotii has the potential to be developed as an effective therapeutic agent against the growth of breast cancer cells. View Full-Text
Keywords: anticancer; Ricinodendron heudelotii; chemoprevention anticancer; Ricinodendron heudelotii; chemoprevention
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MDPI and ACS Style

Yakubu, O.F.; Adebayo, A.H.; Dokunmu, T.M.; Zhang, Y.-J.; Iweala, E.E.J. Cytotoxic Effects of Compounds Isolated from Ricinodendron heudelotii. Molecules 2019, 24, 145. https://doi.org/10.3390/molecules24010145

AMA Style

Yakubu OF, Adebayo AH, Dokunmu TM, Zhang Y-J, Iweala EEJ. Cytotoxic Effects of Compounds Isolated from Ricinodendron heudelotii. Molecules. 2019; 24(1):145. https://doi.org/10.3390/molecules24010145

Chicago/Turabian Style

Yakubu, Omolara F.; Adebayo, Abiodun H.; Dokunmu, Titilope M.; Zhang, Ying-Jun; Iweala, Emeka E.J. 2019. "Cytotoxic Effects of Compounds Isolated from Ricinodendron heudelotii" Molecules 24, no. 1: 145. https://doi.org/10.3390/molecules24010145

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