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Molecules 2018, 23(9), 2154;

Ionic Liquids: Efficient Media for the Lipase-Catalyzed Michael Addition

College of Chemistry and Chemical Engineering, Henan Polytechnic University, Jiaozuo 454003, China
Author to whom correspondence should be addressed.
Received: 5 August 2018 / Revised: 18 August 2018 / Accepted: 25 August 2018 / Published: 27 August 2018
(This article belongs to the Special Issue Green and Sustainable Solvents)
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Recently, ionic liquids (ILs) have been regarded as ideal media for non-aqueous bio-catalysis. In this work, the synthesis of warfarin by the lipase-catalyzed Michael addition in IL media and the parameters that affected the warfarin yield were investigated. Experimental results demonstrated that the chemical structures of the ILs were a major factor for influencing the warfarin yield. The ILs containing the NTf2 anion were suitable reaction media due to the high chemical stability of this anion. The incorporation of the hydroxyl group on the IL cation significantly improved the lipase activity due to the H2O-mimicking property of this group. The lipase activity decreased by increasing the alkyl chain length on the IL cation due to the non-polar domain formation of the IL cation at the active site entrance of lipase. The ILs and lipase could be reused no less than five times without reduction in the warfarin yield. View Full-Text
Keywords: ionic liquids (ILs); lipase; Michael addition; warfarin; bio-catalysis ionic liquids (ILs); lipase; Michael addition; warfarin; bio-catalysis

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Fan, Y.; Cai, D.; Wang, X.; Yang, L. Ionic Liquids: Efficient Media for the Lipase-Catalyzed Michael Addition. Molecules 2018, 23, 2154.

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