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Molecules 2018, 23(7), 1640; https://doi.org/10.3390/molecules23071640

Development of Dermal Films Containing Miconazole Nitrate

1
Faculty of Pharmacy, “Grigore T. Popa”, University of Medicine and Pharmacy of Iași, Iași 700115, Romania
2
Faculty of Pharmacy, University of Medicine and Pharmacy of Tîrgu Mureș, Târgu Mureş 540001, Romania
*
Author to whom correspondence should be addressed.
Received: 7 June 2018 / Revised: 2 July 2018 / Accepted: 4 July 2018 / Published: 5 July 2018
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Abstract

This study aims to develop new antifungal dermal films based on their mechanical properties (elongation, adhesion, behaviour towards vapour moisture) and the in vitro availability of miconazole nitrate, used as a pharmaceutical active ingredient in various concentrations. The three polymeric films prepared were translucent or shiny, with the surface of 63.585 cm2, 0.20–0.30 mm thickness, and content of miconazole nitrate of 3.931 or 15.726 mg·cm2. The mechanical resistance and elongation tests demonstrated that the two films based on hydroxyethyl cellulose (HEC) polymer were more elastic than the one prepared with hydroxypropyl methylcellulose (HPMC). The vapour water absorption and vapour water loss capacity of the films revealed that the HPMC film did not dry very well in the process of preparation by the evaporation of the solvent technique, unlike the HEC films that jellified more evenly in water and had higher drying capacity at 40 °C. The in vitro availability of miconazole nitrate from dermal films was evaluated using the Franz diffusion cell method, through a synthetic membrane (Ø 25 mm × 0.45 µm) and acceptor media with pH 7.4 (phosphate buffer and sodium lauryl sulphate 0.045%), resulting a release rate of up to 70%. View Full-Text
Keywords: miconazole nitrate; hydroxypropyl methylcellulose; hydroxyethyl cellulose; Franz cell; dermal films miconazole nitrate; hydroxypropyl methylcellulose; hydroxyethyl cellulose; Franz cell; dermal films
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Bîrsan, M.; Apostu, M.; Todoran, N.; Antonoaea, P.; Rusu, A.; Ciurba, A. Development of Dermal Films Containing Miconazole Nitrate. Molecules 2018, 23, 1640.

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