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Nanotechnology for Cancer Therapy Based on Chemotherapy

The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an 710049, China
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Authors to whom correspondence should be addressed.
These authors contribute equally to this work.
Molecules 2018, 23(4), 826; https://doi.org/10.3390/molecules23040826
Received: 27 February 2018 / Revised: 27 March 2018 / Accepted: 29 March 2018 / Published: 4 April 2018
(This article belongs to the Collection Nanomedicine)
Chemotherapy has been widely applied in clinics. However, the therapeutic potential of chemotherapy against cancer is seriously dissatisfactory due to the nonspecific drug distribution, multidrug resistance (MDR) and the heterogeneity of cancer. Therefore, combinational therapy based on chemotherapy mediated by nanotechnology, has been the trend in clinical research at present, which can result in a remarkably increased therapeutic efficiency with few side effects to normal tissues. Moreover, to achieve the accurate pre-diagnosis and real-time monitoring for tumor, the research of nano-theranostics, which integrates diagnosis with treatment process, is a promising field in cancer treatment. In this review, the recent studies on combinational therapy based on chemotherapy will be systematically discussed. Furthermore, as a current trend in cancer treatment, advance in theranostic nanoparticles based on chemotherapy will be exemplified briefly. Finally, the present challenges and improvement tips will be presented in combination therapy and nano-theranostics. View Full-Text
Keywords: chemotherapy; nanoparticles; combination therapy; theranostic nanoparticles; cancer chemotherapy; nanoparticles; combination therapy; theranostic nanoparticles; cancer
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Zhao, C.-Y.; Cheng, R.; Yang, Z.; Tian, Z.-M. Nanotechnology for Cancer Therapy Based on Chemotherapy. Molecules 2018, 23, 826.

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