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Open AccessArticle

Biodegradable and pH Sensitive Peptide Based Hydrogel as Controlled Release System for Antibacterial Wound Dressing Application

1
Key Laboratory of Textile Science and Technology, Ministry of Education, College of Textiles, Donghua University, Songjiang District, Shanghai 201620, China
2
Modern Textile Institute, Donghua University, Changning District, Shanghai 200051, China
*
Authors to whom correspondence should be addressed.
Molecules 2018, 23(12), 3383; https://doi.org/10.3390/molecules23123383
Received: 15 November 2018 / Revised: 10 December 2018 / Accepted: 12 December 2018 / Published: 19 December 2018
(This article belongs to the Special Issue Supramolecular Gel)
The stimuli-sensitive and biodegradable hydrogels are promising biomaterials as controlled drug delivery systems for diverse biomedical applications. In this study, we construct hybrid hydrogels combined with peptide-based bis-acrylate and acrylic acid (AAc). The peptide-based bis-acrylate/AAc hybrid hydrogel displays an interconnected and porous structure by scanning electron microscopy (SEM) observation and exhibits pH-dependent swelling property. The biodegradation of hybrid hydrogels was characterized by SEM and weight loss, and the results showed the hydrogels have a good enzymatic biodegradation property. The mechanical and cytotoxicity properties of the hydrogels were also tested. Besides, triclosan was preloaded during the hydrogel formation for drug release and antibacterial studies. In summary, the peptide-based bis-acrylate/AAc hydrogel with stimuli sensitivity and biodegradable property may be excellent candidates as drug delivery systems for antibacterial wound dressing application. View Full-Text
Keywords: hydrogel; peptide; acrylic acid; biodegradable; pH-sensitive hydrogel; peptide; acrylic acid; biodegradable; pH-sensitive
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MDPI and ACS Style

Zhu, J.; Han, H.; Ye, T.-T.; Li, F.-X.; Wang, X.-L.; Yu, J.-Y.; Wu, D.-Q. Biodegradable and pH Sensitive Peptide Based Hydrogel as Controlled Release System for Antibacterial Wound Dressing Application. Molecules 2018, 23, 3383.

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