Anti-Carcinogenic Glucosinolates in Cruciferous Vegetables and Their Antagonistic Effects on Prevention of Cancers
Abstract
:1. Introduction
2. Epidemiological Studies of ITCs
3. Molecular Mechanism of ITCs in Cancer Prevention
3.1. Benzyl Isothiocyanate
3.1.1. Blood
3.1.2. Breast
3.1.3. Brain
3.1.4. Colon
3.1.5. Pancreatic
3.2. Phenethyl Isothiocyanate
3.2.1. Blood
3.2.2. Breast
3.2.3. Colon
3.2.4. Ovary
3.2.5. Prostate
3.3. Sulforaphane
3.3.1. Brain
3.3.2. Breast
3.3.3. Colon
3.3.4. Prostate
3.3.5. Skin
4. ROS-Nrf2-ARE Mediated Pathways in Downregulation of NF-κB
5. Direct and Indirect Inhibition of NF-κB by ITCs
6. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Isothiocyanate | Benzyl Isothiocyanate (BITC) | Phenethyl Isothiocyanate (PEITC) | Sulforaphane (SFN) |
---|---|---|---|
Dietary Source | Cabbage, garden cress, Indian cress | Watercress/turnip | Broccoli, Brussels sprouts, cabbage |
Precursor | Glucotropaeolin | Gluconasturtiin | Glucoraphanin |
Structure |
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Soundararajan, P.; Kim, J.S. Anti-Carcinogenic Glucosinolates in Cruciferous Vegetables and Their Antagonistic Effects on Prevention of Cancers. Molecules 2018, 23, 2983. https://doi.org/10.3390/molecules23112983
Soundararajan P, Kim JS. Anti-Carcinogenic Glucosinolates in Cruciferous Vegetables and Their Antagonistic Effects on Prevention of Cancers. Molecules. 2018; 23(11):2983. https://doi.org/10.3390/molecules23112983
Chicago/Turabian StyleSoundararajan, Prabhakaran, and Jung Sun Kim. 2018. "Anti-Carcinogenic Glucosinolates in Cruciferous Vegetables and Their Antagonistic Effects on Prevention of Cancers" Molecules 23, no. 11: 2983. https://doi.org/10.3390/molecules23112983