Next Article in Journal
Synthesis and Biological Activity of Novel O-Alkyl Derivatives of Naringenin and Their Oximes
Next Article in Special Issue
A Systematic Review of Computational Drug Discovery, Development, and Repurposing for Ebola Virus Disease Treatment
Previous Article in Journal
Masticadienonic and 3α-OH Masticadienoic Acids Induce Apoptosis and Inhibit Cell Proliferation and Tumor Growth in Prostate Cancer Xenografts in Vivo
Previous Article in Special Issue
Novel Selective Estrogen Receptor Ligand Conjugates Incorporating Endoxifen-Combretastatin and Cyclofenil-Combretastatin Hybrid Scaffolds: Synthesis and Biochemical Evaluation
Article Menu
Issue 9 (September) cover image

Export Article

Open AccessCommunication
Molecules 2017, 22(9), 1375;

MTLD, a Database of Multiple Target Ligands, the Updated Version

North China Institute of Science and Technology, Beijing 065201, China
Institute of Medicinal Biotechnology, Chinese Academy of Medical Science, Beijing 100050, China
Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC H3T 1E2, Canada
Author to whom correspondence should be addressed.
Received: 3 July 2017 / Revised: 14 August 2017 / Accepted: 16 August 2017 / Published: 6 September 2017
(This article belongs to the Special Issue Polypharmacology and Multitarget Drug Discovery)
Full-Text   |   PDF [2424 KB, uploaded 6 September 2017]   |  


Polypharmacology plays an important role in drug discovery and polypharmacology drug strategies provide a novel path in drug design. However, to develop a polypharmacology drug with the desired profile remains a challenge. Previously, we developed a free web-accessible database called Multiple Target Ligand Database (MTLD, Herein, the MTLD database has been updated, containing 2444 Multiple Target Ligands (MTLs) that bind with 21,424 binding sites from 18,231 crystal structures. Of the MTLs, 304 entries are approved drugs, and 1911 entries are drug-like compounds. Also, we added new functions such as multiple conditional search and linkage visualization. Through querying the updated database, extremely useful information for the development of polypharmacology drugs may be provided. View Full-Text
Keywords: polypharmacology; Multiple Target Ligands (MTLs); drug discovery; database polypharmacology; Multiple Target Ligands (MTLs); drug discovery; database

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Chen, C.; Wu, M.; Cen, S.; Wu, J.; Zhou, J. MTLD, a Database of Multiple Target Ligands, the Updated Version. Molecules 2017, 22, 1375.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top