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Open AccessArticle

In Vivo Dual-Modality Fluorescence and Magnetic Resonance Imaging-Guided Lymph Node Mapping with Good Biocompatibility Manganese Oxide Nanoparticles

by Yonghua Zhan 1,2,†, Wenhua Zhan 3,4,†, Hanrui Li 1, Xinyi Xu 1, Xu Cao 1, Shouping Zhu 1, Jimin Liang 1,* and Xueli Chen 1,*
1
Engineering Research Center of Molecular and Neuro Imaging of the Ministry of Education, School of Life Science and Technology, Xidian University, Xi’an 710071, Shaanxi, China
2
Xidian-Ningbo Information Technology Institute, Xidian University, Xi’an 710071, Shaanxi, China
3
Department of Radiotherapy, General Hospital of Ningxia Medical University, Yinchuan 750004, Ningxia, China
4
Key Laboratory of Biomedical Information Engineering of Education Ministry, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an 710049, Shaanxi, China
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Molecules 2017, 22(12), 2208; https://doi.org/10.3390/molecules22122208
Received: 16 October 2017 / Revised: 8 December 2017 / Accepted: 10 December 2017 / Published: 12 December 2017
(This article belongs to the Special Issue Applications of Magnetic Nanoparticles in Biomedicine)
Multifunctional manganese oxide nanoparticles (NPs) with impressive enhanced T1 contrast ability show great promise in biomedical diagnosis. Herein, we developed a dual-modality imaging agent system based on polyethylene glycol (PEG)-coated manganese oxide NPs conjugated with organic dye (Cy7.5), which functions as a fluorescence imaging (FI) agent as well as a magnetic resonance imaging (MRI) imaging agent. The formed Mn3O4@PEG-Cy7.5 NPs with the size of ~10 nm exhibit good colloidal stability in different physiological media. Serial FI and MRI studies that non-invasively assessed the bio-distribution pattern and the feasibility for in vivo dual-modality imaging-guided lymph node mapping have been investigated. In addition, histological and biochemical analyses exhibited low toxicity even at a dose of 20 mg/kg in vivo. Since Mn3O4@PEG-Cy7.5 NPs exhibited desirable properties as imaging agents and good biocompatibility, this work offers a robust, safe, and accurate diagnostic platform based on manganese oxide NPs for tumor metastasis diagnosis. View Full-Text
Keywords: manganese oxide nanoparticles; fluorescence imaging; magnetic resonance imaging; lymph node; dual-modality manganese oxide nanoparticles; fluorescence imaging; magnetic resonance imaging; lymph node; dual-modality
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MDPI and ACS Style

Zhan, Y.; Zhan, W.; Li, H.; Xu, X.; Cao, X.; Zhu, S.; Liang, J.; Chen, X. In Vivo Dual-Modality Fluorescence and Magnetic Resonance Imaging-Guided Lymph Node Mapping with Good Biocompatibility Manganese Oxide Nanoparticles. Molecules 2017, 22, 2208.

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