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Molecules 2016, 21(6), 783;

Antispasmodic Effects and Action Mechanism of Essential Oil of Chrysactinia mexicana A. Gray on Rabbit Ileum

Departamento de Farmacología y Fisiología (Fisiología), Facultad de Veterinaria, Universidad de Zaragoza, Miguel Servet 177, 50013 Zaragoza, Spain
Dirección General de Servicios Educativos Iztapalapa, Av. Rojo Gómez No. 1149, Col. Barrio San Pedro, Del Iztapalapa 09300 México, DF, Mexico
Instituto de Investigación Sanitaria de Aragón (IIS-Aragón), 50013 Zaragoza, Spain
Instituto Agroalimentario de Aragón (IA2), 50013 Zaragoza, Spain
Departamento de Sistemas Biológicos, Universidad Autónoma Metropolitana-Xochimilco, Calzada del Hueso 1100, Colonia Villa Quietud, Coyoacán, 09340 Mexico, DF, Mexico
Present Address: División de Ciencias Biológicas y de la Salud, Universidad de la Costa, Carretera al Libramiento Paraje de las Pulgas s/n, Colonia Cuauhtémoc, Santiago Pinotepa Nacional, Oaxaca 71600, Mexico
Author to whom correspondence should be addressed.
Academic Editor: Luca Forti
Received: 22 March 2016 / Revised: 8 June 2016 / Accepted: 12 June 2016 / Published: 16 June 2016
(This article belongs to the Collection Recent Advances in Flavors and Fragrances)
Full-Text   |   PDF [1445 KB, uploaded 16 June 2016]   |  


The Chrysactinia mexicana A. Gray (C. mexicana) plant is used in folk medicine to treat fever and rheumatism; it is used as a diuretic, antispasmodic; and it is used for its aphrodisiac properties. This study investigates the effects of the essential oil of C. mexicana (EOCM) on the contractility of rabbit ileum and the mechanisms of action involved. Muscle contractility studies in vitro in an organ bath to evaluate the response to EOCM were performed in the rabbit ileum. EOCM (1–100 µg·mL−1) reduced the amplitude and area under the curve of spontaneous contractions of the ileum. The contractions induced by carbachol 1 µM, potassium chloride (KCl) 60 mM or Bay K8644 1 µM were reduced by EOCM (30 µg·mL−1). Apamin 1 µM and charybdotoxin 0.01 µM decreased the inhibition induced by EOCM. The d-cAMP 1 µM decreased the inhibition induced by EOCM. l-NNA 10 µM, Rp-8-Br-PET-cGMPS 1 µM, d,l-propargylglycine 2 mM, or aminooxyacetic acid hemihydrochloride 2 mM did not modify the EOCM effect. In conclusion, EOCM induces an antispasmodic effect and could be used in the treatment of intestinal spasms or diarrhea processes. This effect would be mediated by Ca2+, Ca2+-activated K+ channels and cAMP. View Full-Text
Keywords: Chrysactinia mexicana; essential oil; antispasmodic effect; ileum; rabbit; intestinal motility Chrysactinia mexicana; essential oil; antispasmodic effect; ileum; rabbit; intestinal motility

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Zavala-Mendoza, D.; Grasa, L.; Zavala-Sánchez, M.Á.; Pérez-Gutiérrez, S.; Murillo, M.D. Antispasmodic Effects and Action Mechanism of Essential Oil of Chrysactinia mexicana A. Gray on Rabbit Ileum. Molecules 2016, 21, 783.

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